Human PDGFRB Protein, Recombinant

产品货号：PR00129HuP1
   
$ 询价

规格    100ug

产品名称：Human PDGFRB Protein, Recombinant
 
纯度：≥95 % as determined by SDS-PAGE
 
内毒素：/
 
生物活性：/
 
序列起止：Leu33~Ala403
 
标签：C-His tag
 
Uniprot链接：P09619
 
表达系统：E.coli
 
种属：Human
 
预测 N 端：Met
 
预测分子量：42.73
 
缓冲液：20mM Tris, 250mM imidazole, 500mM NaCl, pH8.0, containing 10% glycerol.
 
运输方式：This Protein is shipped as lyophilized powder at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
稳定性 & 储存条件：Store for up to one year at -20°C to -80°C as lyophilized powder.
 
复溶：Please refer to COA for detailed information
 
质量验证图：/

别称：PDGFR/PDGFR1/CD140b
 
背景信息：Background: PDGF R beta. PDGF is a major serum mitogen that can exist as a homo or hetero-dimeric protein consisting of disulfide-linked PDGF-A and PDGF-B chains. The PDGF-AA,PDGF-BB and PDGF-AB isoforms have been shown to bind to two distinct cell surface PDGF receptors with different affinities. Where as PDGF R alpha  binds all three PDGF isoforms with high affinity, PDGF R beta  binds PDGF-BB only with high-affinity. Both PDGF R alpha  and PDGF R beta  are members of the class III subfamily of receptor tyrosine kinases (RTK) that also includes the receptors for M-CSF, SCF and Flt3 ligand. All class III RTKs are characterized by the presence offive immunoglobulin-like domains in their extracellular region and a split kinase domain in their intracellular region. PDGF binding induces receptor homo-andhetero-dimerization and signal transduction. The expression of the  alpha  and  beta  receptors is independently regulated in various cell types. Recombinant soluble PDGF R beta  binds PDGF with high affinity and is potent PDGF antagonist. 

全称：Platelet Derived Growth Factor Receptor Beta (PDGFRB)

说明书：待上传