Human COL1A1 Protein, Recombinant


产品货号:PR01108HuP1
   
询价

规格    100ug

产品名称Human COL1A1 Protein, Recombinant
 
纯度≥95 % as determined by SDS-PAGE
 
内毒素/
 
生物活性/
 
序列起止Gln23~Pro161
 
标签C-His tag
 
Uniprot链接P02452
 
表达系统E.coli
 
种属Human
 
预测 N 端Met
 
预测分子量16.16
 
缓冲液20mM Tris, 250mM imidazole, 500mM NaCl, pH8.0, containing 10% glycerol.
 
运输方式This Protein is shipped as lyophilized powder at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
稳定性 & 储存条件Store for up to one year at -20°C to -80°C as lyophilized powder.
 
复溶Please refer to COA for detailed information
 
质量验证图:/

别称Alpha-1 type I collagen
 
背景信息Background: Collagen I alpha 1. Type I collagen is the most abundant structural protein of connective tissues such as skin, bone and tendon. It is synthesized as a procollagen molecule which is characterized by a 300 nm triple helical domain flanked by globular N- and C-terminal propeptides (1). The triple helical domain contains Gly-Xaa-Yaa triplets where Xaa and Yaa are frequently proline and hydroxyproline, respectively. The non-helical propeptides are removed by procollagen N- and C-proteinase activities so that the mature triple helices can self-assemble into collagen fibrils that provide tensile strength to tissues (1). Type I collagen is a heterotrimer that consists of two  alpha 1(I) chains and one  alpha 2(I) chain, although homotrimers consisting of three identical  alpha 1(I) chains have also been described (2). This recombinant mini pro-alpha 1(I) collagen consists of a shortened  alpha 1(I) chain with following domain structure from N- to C-terminus: N-propeptide, N‑telopeptide, the 33 most N-terminal Gly-Xaa-Yaa repeats, the 33 most C-terminal Gly-Xaa-Yaa repeats, C-telopeptide and C-propeptide. The preparation contains a mixture of the full-length molecule, pN collagen I( alpha 1) and the C-terminal propeptide. This truncated pro-alpha 1(I) collagen is a substrate for procollagen N-proteinase and procollagen C-proteinase.

全称Collagen alpha-1(I) chain (COL1A1)

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