Human IL11 Protein, Recombinant

产品货号：PR00619HuM1
   
$ 询价

规格    100ug

产品名称：Human IL11 Protein, Recombinant
 
纯度：≥95 % as determined by SDS-PAGE
 
内毒素：< 1.0 EU per μg of the protein as determined by the LAL method
 
生物活性：/
 
序列起止：Pro22~Leu199
 
标签：N-His tag
 
Uniprot链接：P20809
 
表达系统：293F
 
种属：Human
 
预测 N 端：Met
 
预测分子量：/
 
缓冲液：20mM Tris, 250mM imidazole, 500mM NaCl, pH8.0, containing 10% glycerol.
 
运输方式：This Protein is shipped as lyophilized powder at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
稳定性 & 储存条件：Store for up to one year at -20°C to -80°C as lyophilized powder.
 
复溶：Please refer to COA for detailed information
 
质量验证图：/

别称：IL-11/AGIF
 
背景信息：Background: IL-11. IL-11 (Interleukin 11) is a pleiotropic cytokine in the IL-6 family, which also includes LIF, CNTF, Oncostatin M, Cardiotrophin-1, IL-27 and IL-31 (1-4). In humans, IL-11 was also independently discovered as an adipogenesis inhibitory factor (AGIF) (3). The mouse IL-11 cDNA encodes a 199 amino acid (aa) precursor, which generates a 178 aa, 19 kDa mature unglycosylated protein. Mature mouse IL-11 shares 88%, 97%, and 89% aa sequence identity with human, rat and canine IL-11, respectively. IL-11 is secreted by osteoblasts, synoviocytes, fibroblasts, chondrocytes, intestinal myofibroblasts, and trophoblasts, among other cell types (1). It is found in the plasma mainly during inflammation, such as that associated with viral infection, cancer, or inflammatory arthritis, and is considered to be primarily anti‑inflammatory (1). It stimulates hematopoiesis and thrombopoiesis, regulates macrophage differentiation, and confers mucosal protection in the intestine (1). It has also been found to enhance T cell polarization toward Th2, promote B cell IgG production, increase osteoclast bone absorption, protect endothelial cells from oxidative stress, and regulate epithelial proliferation and apoptosis (1). IL-11 synergizes with several other cytokines to produce these effects, and its effects overlap with those of IL-6 (1). IL-11 receptor activation requires formation of a complex of two IL-11 molecules with two molecules of the ligand-binding IL-11 R  alpha  subunit and two molecules of the ubiquitously expressed cell signaling  beta  subunit, gp130 (5). A soluble form of IL-11 R  alpha  can bind IL-11 and either form a signaling complex with gp130 on the cell surface, or inhibit cell surface IL-11 R  alpha /gp130 signaling (6-8).

全称：Interleukin-11 (IL11)

说明书：待上传