Human PCSK9 Protein, Recombinant

产品货号：PR00455HuM1
   
$ 询价

规格    100ug

产品名称：Human PCSK9 Protein, Recombinant
 
纯度：≥95 % as determined by SDS-PAGE
 
内毒素：< 1.0 EU per μg of the protein as determined by the LAL method
 
生物活性：/
 
序列起止：Met1~Gln692
 
标签：N-His tag
 
Uniprot链接：Q8NBP7
 
表达系统：293F
 
种属：Human
 
预测 N 端：Met
 
预测分子量：74.3
 
缓冲液：20mM Tris, 250mM imidazole, 500mM NaCl, pH8.0, containing 10% glycerol.
 
运输方式：This Protein is shipped as lyophilized powder at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
稳定性 & 储存条件：Store for up to one year at -20°C to -80°C as lyophilized powder.
 
复溶：Please refer to COA for detailed information
 
质量验证图：/

别称：Narc1
 
背景信息：Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a crucial protein governing the circulating levels of low density lipoprotein-cholesterol (LDL-C), by virtue of its pivotal role in the degradation of the LDL receptor (LDLR). PCSK9 is expressed in the kidney and lung. It is synthesized as a 72 kDa immature precursor that undergoes autocatalytic cleavage in the endoplasmic reticulum to generate a 63 kDa mature protein. The cleaved N-terminal fragment remains associated with the mature protein and is necessary for its secretion, allowing it to circulate in the blood. The ability of PCSK9 to regulate a diverse group of cell-surface proteins hinted that it might also be able to influence additional membrane proteins that are important in anti-tumour immune responses. Targeting PCSK9 to treat cancer is also attractive because two neutralizing antibodies against it, evolocumab and alirocumab, have already been approved for human clinical use to lower cholesterol levels. (PMID: 30522786, PMID: 22493497)

全称：Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9)

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