Human IL10 Protein, Recombinant

产品货号：PR00189HuM1
   
$ 询价

规格    100ug

产品名称：Human IL10 Protein, Recombinant
 
纯度：≥95 % as determined by SDS-PAGE
 
内毒素：< 1.0 EU per μg of the protein as determined by the LAL method
 
生物活性：/
 
序列起止：Ser19~Asn178
 
标签：N-His tag
 
Uniprot链接：P22301
 
表达系统：293F
 
种属：Human
 
预测 N 端：Met
 
预测分子量：17.6
 
缓冲液：20mM Tris, 250mM imidazole, 500mM NaCl, pH8.0, containing 10% glycerol.
 
运输方式：This Protein is shipped as lyophilized powder at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
稳定性 & 储存条件：Store for up to one year at -20°C to -80°C as lyophilized powder.
 
复溶：Please refer to COA for detailed information
 
质量验证图：/

别称：CSIF IL-10
 
背景信息：The human IL10 gene is 4.7 kb in size and is located on the long arm of chromosome 1. It contains five exons. Biologically functional IL-10 exists in the form of a 36 kDa homodimer composed of two non-covalently bonded mono-mers each with 160 amino acids length. IL-10 is an anti-inflammatory cytokine, produced by T helper (Th) cells, macrophages, monocytes, and B cells, that plays a crucial role in preventing inflammatory and autoimmune pathologies. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-B activity, and is involved in the regulation of the JAK-STAT signaling pathway. IL-10, along with its receptors, describes an important role in pathogenesis of various diseases, including infectious, inflammatory, autoimmune diseases. IL-10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.

全称：Interleukin-10 (IL10)

说明书：待上传