Human KDR Protein, Recombinant

产品货号：PR00295HuP2
   
$ 询价

规格    100ug

产品名称：Human KDR Protein, Recombinant
 
纯度：≥95 % as determined by SDS-PAGE
 
内毒素：/
 
生物活性：/
 
序列起止：Ala20~Glu764
 
标签：C-His tag
 
Uniprot链接：P35968
 
表达系统：E.coli
 
种属：Human
 
预测 N 端：Met
 
预测分子量：83.87 kDa
 
缓冲液：20mM Tris, 250mM imidazole, 500mM NaCl, pH8.0, containing 10% glycerol.
 
运输方式：This Protein is shipped as lyophilized powder at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
稳定性 & 储存条件：Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
 
复溶：Please refer to COA for detailed information
 
质量验证图：/

别称：CD309, FLK1, VEGFR, KDR, A Type III Receptor Tyrosine Kinase, Kinase Insert Domain Receptor, Kinase Insert Domain Receptor, Fetal Liver Kinase-1
 
背景信息：VEGFR2/KDR/Flk-1. VEGFR2 (KDR/Flk-1), VEGFR1 (Flt-1) and VEGFR3 (Flt-4) belong to the class III subfamily of receptor tyrosine kinases (RTKs). All three receptors contain seven immunoglobulin-like repeats in their extracellular domains and kinase insert domains in their intracellular regions. The expression of VEGFR1, 2, and 3 is almost exclusively restricted to the endothelial cells. These receptors are likely to play essential roles in vasculogenesis and angiogenesis. Mouse VEGFR2 cDNA encodes a 1367 amino acid (aa) residue precursor protein with a 19 aa residue signal peptide. Mature VEGFR2 is composed of a 743 aa residue extracellular domain, a 22 aa residue transmembrane domain and a 583 aa residue cytoplasmic domain. In contrast to VEGFR1 which binds both PlGF and VEGF with high affinity, VEGFR2 binds VEGF but not PlGF with high affinity. The recombinant soluble VEGFR2 Fc Chimera binds VEGF with high affinity and is a potent VEGF antagonist.

全称：Vascular endothelial growth factor receptor 2 (KDR)

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