Human BACE1 Protein, Recombinant

产品货号：PR00427HuP1
   
$ 询价

规格：100ug

产品名称：Human BACE1 Protein, Recombinant
 
纯度：≥95 % as determined by SDS-PAGE
 
内毒素：/
 
生物活性：/
 
序列起止：Phe170~Thr428
 
标签：C-His tag
 
Uniprot链接：P56817
 
表达系统：E.coli
 
种属：Human
 
预测 N 端：Met
 
预测分子量：28.49 kDa
 
缓冲液：20mM Tris, 250mM imidazole, 500mM NaCl, pH8.0, containing 10% glycerol.
 
运输方式：This Protein is shipped as lyophilized powder at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
稳定性 & 储存条件：Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
 
复溶：Please refer to COA for detailed information
 
别称：ASP2, Beta Secretase, Memapsin 2, Aspartyl protease 2, Beta-site amyloid precursor protein cleaving enzyme 1, Membrane-associated aspartic protease 2
 
背景信息：BACE-1. BACE-1 is an aspartic protease and an integral membrane protein (1, 2). It is the major  beta  secretase, and together with the  gamma  secretase, is responsible for generating the amyloid  beta  peptide (A beta ) from the amyloid precursor protein (APP) (3, 4). Because A beta  is a major component of amyloid plaques, BACE-1 has been implicated in the onset and/or progression of Alzheimer's disease. High levels of BACE-1 activity are sufficient to elicit neurodegeneration and neurological decline in vivo, indicating that inhibiting BACE-1 may block not only A beta -dependent but also A beta -independent pathogenic mechanisms (5). In addition to APP, BACE-1 also cleaves APP-like proteins 1 and 2, the cell adhesion protein P-selectin glycoprotein ligand-1 and  beta -galactoside  alpha 2,6-sialyltransferase, implying that BACE-1 may have additional functions involving the ectodomain shedding of membrane proteins (6-8). The purified recombinant mouse BACE-1 corresponds to the ectodomain with the activity as described in Activity Assay Protocol.
 
全称：Beta-secretase 1 (BACE1)
 
说明书：待上传