Human CD3D Protein, Recombinant

产品货号：PR00500HuP1
   
$ 询价

规格：100ug

产品名称：Human CD3D Protein, Recombinant
 
纯度：≥95 % as determined by SDS-PAGE
 
内毒素：/
 
生物活性：/
 
序列起止：Phe22~Ala105
 
标签：C-His tag
 
Uniprot链接：P04234
 
表达系统：E.coli
 
种属：Human
 
预测 N 端：Met
 
预测分子量：9.24 kDa
 
缓冲液：20mM Tris, 250mM imidazole, 500mM NaCl, pH8.0, containing 10% glycerol.
 
运输方式：This Protein is shipped as lyophilized powder at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
稳定性 & 储存条件：Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
 
复溶：Please refer to COA for detailed information
 
别称：CD3-DELTA, T3D, T-Dell Surface Glycoprotein CD3 Delta Chain, T-cell receptor T3 delta chain
 
背景信息：CD3 delta/CD3d. CD3d, also known asCD3 delta and T3D, is a single-pass type I membrane protein. CD3 delta/CD3d is part ofthe T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-celldevelopment and signal transduction (1). The encoded membrane proteinrepresents the delta subunit of the CD3 complex, and along with four other CD3subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complexon the surface of T cells (2). CD3 delta/CD3d contains an 84 amino acid extracellular domain,a 21 amino acid transmembrane domain, and a 45 amino acid cytoplasmic domain.Human CD3 delta/CD3d shares 89%, 61%, and 57% sequence identity in its extracellulardomain with its cynomolgus monkey, rat, and mouse homologs, respectively. CD3 delta/CD3d,like other subunit members CD3G and CD3E of the TCR-CD3 complex, contains anextracellular Ig domain and a single immunoreceptor tyrosine-based activationmotif (3, 4).  Defectsin CD3 delta/CD3d cause severe combined immunodeficiency autosomal recessiveT-cell-negative/B-cell-positive/NK-cell-positive (T-/B+/NK+ SCID) which isa genetically and clinically heterogeneous group of rare congenital disorderscharacterized by impairment of both humoral and cell-mediated immunity, leukopenia,and low or absent antibody levels (5, 6).
 
全称：T-cell surface glycoprotein CD3 delta chain (CD3D)
 
说明书：待上传