Human DKK3 Protein, Recombinant
产品货号:PR00523HuP1
$ 询价
规格:100ug
产品名称:Human DKK3 Protein, Recombinant
纯度:≥95 % as determined by SDS-PAGE
内毒素:/
生物活性:/
序列起止:Ala22~Ile350
标签:/
Uniprot链接:Q9UBP4
表达系统:E.coli
种属:Human
预测 N 端:Met
预测分子量:/
缓冲液:20mM Tris, 250mM imidazole, 500mM NaCl, pH8.0, containing 10% glycerol.
运输方式:This Protein is shipped as lyophilized powder at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
稳定性 & 储存条件:Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
复溶:Please refer to COA for detailed information
别称:REIC
背景信息:DKK3, also named as REIC, belongs to the dickkopf family. It antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimers disea. The adenovirus carrying REIC/Dkk-3 (Ad-REIC) exhibits a potent tumor-specific cell-killing function for various human cancers. It has also become evident that some human cancers are resistant to Ad-REIC-induced apoptosis. The DKK3 is a Glycosylation protein with MW about 55 kDa or 38-43 kDa.
全称:Dickkopf-related protein 3 (DKK3)
说明书:待上传