Human TNFRSF1B Protein, Recombinant

产品货号：PR00583HuP1
   
$ 询价

规格：100ug

产品名称：Human TNFRSF1B Protein, Recombinant
 
纯度：≥95 % as determined by SDS-PAGE
 
内毒素：/
 
生物活性：/
 
序列起止：Pro24~Thr206
 
标签：C-His tag
 
Uniprot链接：P20333
 
表达系统：E.coli
 
种属：Human
 
预测 N 端：Met
 
预测分子量：/
 
缓冲液：20mM Tris, 250mM imidazole, 500mM NaCl, pH8.0, containing 10% glycerol.
 
运输方式：This Protein is shipped as lyophilized powder at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
稳定性 & 储存条件：Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
 
复溶：Please refer to COA for detailed information
 
别称：CD120B, P75, TBPII, TNF-R-II, TNF-R75, TNFBR, TNFR2, TNFR80, P75tnfr, Tumor necrosis factor receptor 2, p80 TNF-alpha receptor, Etanercept
 
背景信息：TNF RII/TNFRSF1B. Two types of soluble TNF receptors have beenidentified in human serum and urine which can neutralize the biological activitiesof TNF-alpha and TNF-beta (1, 2). These binding proteins represent truncatedforms of the two types of high-affinity cell surface receptors for TNF(TNFR-p60 Type B and TNFR-p80 Type A). Soluble TNF RII corresponds to TNFR-p80Type A (3). In the new TNF superfamily nomenclature, TNF RII is referred to asTNFRSF1B. These apparent soluble forms of the receptors appear to arise as aresult of shedding of the extracellular domains of the membrane-boundreceptors. Normal concentrations as high as 4 ng/mL are found in the serum ofhealthy individuals, and even higher levels may be found in some pathologicalconditions (4). Mature mouse TNF RII contains an extracellular domain (ECD, aa23 - 258) containing ten disulfide bonds, a transmembrane domain (aa 259-288),and a cytoplasmic domain (aa 289-474). Within the ECD, the mouse TNF RIIshares 57% and 84% aa sequence identity tohuman and rat TNF RII. TNF RII is expressed predominantly on cells of the hematopoietic lineage, such as T and natural killer cells, as well as on endothelial cells, microglia,astrocytes, neurons, oligodendrocytes, cardiac myocytes, and thymocytes (5-7). TNF RII activation primarily initiates pro-inflammatory and pro-survivalresponses via NF kappa B-dependent signaling pathways (5, 8). However, undercertain conditions, TNF RII signaling can induce apoptosis (5). Soluble TNF RIIis believed to inhibit TNF biological activity by binding TNF therebypreventing it from activating membrane TNF receptors (9).
 
全称：Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B)
 
说明书：待上传