Human BMP4 Protein, Recombinant

产品货号：PR00639HuP1

$ 询价

规格：100ug

产品名称：Human BMP4 Protein, Recombinant
 
纯度：≥95 % as determined by SDS-PAGE
 
内毒素：/
 
生物活性：/
 
序列起止：Ser293~Arg408
 
标签：C-His tag
 
Uniprot链接：P12644
 
表达系统：E.coli
 
种属：Human
 
预测 N 端：Met
 
预测分子量：/
 
缓冲液：20mM Tris, 250mM imidazole, 500mM NaCl, pH8.0, containing 10% glycerol.
 
运输方式：This Protein is shipped as lyophilized powder at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
稳定性 & 储存条件：Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
 
复溶：Please refer to COA for detailed information
 
别称：BMP4
 
背景信息：BMP-4. Bonemorphogenetic protein 4 (BMP-4) is a TGF-beta superfamily ligand that is widelyexpressed from early embryogenesis through adulthood. It plays an importantrole in mesenchyme formation, epidermal determination, suppression of neuralinduction, the development of multiple organs, and tissue repair (1-5). It isan integral part of many stem cell differentiation pathways, including lungtissue, (6), adipogenesis (7) and osteogenesis (8, 9). The human BMP-4 precursorcontains a 273 amino acid (aa) propeptide and a 116 amino acid (aa) mature protein (10). Processingof the propeptide by furin or proprotein convertase 6 enables the formation ofthe mature disulfide-linked homodimeric BMP-4 and facilitates its secretion.Similar intracellular processes may lead to the formation and recreation ofBMP4/BMP7 disulfide-linked heterodimer (11-13). Mature human and mouse BMP-4share 98% aa sequence identity. Human BMP-4 shares 85% aa sequence identitywith human BMP-2 and less than 50% with other human BMPs. In Xenopus, BMP-4dimers provide ventralizing signals for existing mesoderm (14). BMP-4 signalsthrough tetrameric complexes composed of type I (primarily Activin RIA orBMPR-IA) and type II (primarily Activin RIIA or BMPR-II) receptors (15, 16). Thebioavailability of BMP-4 is regulated by its interaction with multiple proteinsand glycosaminoglycans (17-19).
 
全称：Bone morphogenetic protein 4 (BMP4)
 
说明书：待上传