Human FABP4 Protein, Recombinant

产品货号：PR00703HuP1
   
$ 询价

规格：100ug

产品名称：Human FABP4 Protein, Recombinant
 
纯度：≥95 % as determined by SDS-PAGE
 
内毒素：/
 
生物活性：/
 
序列起止：Cys2~Ala132
 
标签：C-His tag
 
Uniprot链接：P15090
 
表达系统：E.coli
 
种属：Human
 
预测 N 端：Met
 
预测分子量：/
 
缓冲液：20mM Tris, 250mM imidazole, 500mM NaCl, pH8.0, containing 10% glycerol.
 
运输方式：This Protein is shipped as lyophilized powder at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
稳定性 & 储存条件：Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
 
复溶：Please refer to COA for detailed information
 
别称：A-FABP, AFABP, AP2, Fatty Acid Binding Protein 4, Adipocyte, Adipocyte Protein 2, Adipocyte-type fatty acid-binding protein
 
背景信息：FABP4/A-FABP. Fattyacid binding protein-4 (FABP4; also named A- (adipocyte) FABP, ALBP, oradipocyte protein 2 (aP2)) is a member of a large superfamily of lipid bindingproteins that are expressed in a tissue specific manner (1, 5, 6). FABP4 is oneof ten cytoplasmic FABPs that are 14-15 kDa in size and range from 126-140amino acids (aa) in length (1, 2, 3). Although all are highly conserved in theirtertiary structure, there is only modest aa identity between any two members.The FABP family members are subdivided based on organ or tissue type it wasoriginally expressed or identified; liver- (L-FABP), intestine- (I-FABP), heart-(H-FABP), adipocyte- (A-FABP), epidermal- (E-FABP), ileal- (Il-FABP), brain-(B-FABP), myelin- (M-FABP) and testis-FABP (T-FABP) (1). Mouse A- FABP, the product of the FABP4 gene, is a 132 aacytosolic protein that shows a flattened beta -barrel structure generated by aseries of antiparallel beta -strands and two alpha ‑helices (4, 8). FABP4 is able to bind long-chain fatty acids,retinoic acids or eicosanoids with one mol of ligand bound per mole of protein (1, 8, 9). It is suggested that ligands first bind to theoutside of the molecule, and this binding subsequently induces a conformationalchange in the binding protein, resulting in "internalization" of theligand (4, 7, 9). Mouse FABP4 is 92%, 94% and 91% aa identical to human, rat andcanine FABP4, respectively. It also shows 26% and 28% aa identity to mouseL-FABP and I‑FABP, respectively.
 
全称：Fatty acid-binding protein, adipocyte (FABP4)
 
说明书：待上传