Human SERPINB2 Protein, Recombinant

产品货号：PR00846HuP1
   
$ 询价

规格：100ug

产品名称：Human SERPINB2 Protein, Recombinant
 
纯度：≥95 % as determined by SDS-PAGE
 
内毒素：/
 
生物活性：/
 
序列起止：Glu2~Ala65
 
标签：C-His tag
 
Uniprot链接：P05120
 
表达系统：E.coli
 
种属：Human
 
预测 N 端：Met
 
预测分子量：/
 
缓冲液：20mM Tris, 250mM imidazole, 500mM NaCl, pH8.0, containing 10% glycerol.
 
运输方式：This Protein is shipped as lyophilized powder at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
稳定性 & 储存条件：Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
 
复溶：Please refer to COA for detailed information
 
别称：SERPINB2, PLANH2, Serpin Peptidase Inhibitor Clade B Member 2, Monocyte Arg-serpin, Placental plasminogen activator inhibitor, Serpin B2, Urokinase inhibitor
 
背景信息：Serpin B2. Serpin B2, also known as PAI-2, is an approximately60 kDa serine protease inhibitor (1). It is primarily secreted by macrophagesand monocytes (2, 3) and can form disulfide-linked multimers (4, 5). Serpin B2inhibits both the urokinase-type and tissue-type plasminogen activators (uPAand tPA) (3, 4, 6). Serpin B2 also promotes the clearance of uPA by enhancingits binding and uptake by LRP (7). It limits fibril formation by Huntingtonprotein (HTT) and beta-Amyloid peptides (8). It promotes Th2 biased immuneresponses and is important for intestinal CCL2 production, monocyte recruitment,and nematode clearance (2, 9). A non-glycosylated form of Serpin B2 is retainedintracellularly where it interferes with TNF-a inducedapoptosis by protecting the Retinoblastoma protein (RB1) from calpain digestion(10). It also inhibits proteasome activity in activated endothelial cells (11).Serpin B2 is upregulated in HIV-1 infected PBMC, induces RB1 upregulation, andpromotes HIV-1 replication (12). Human Serpin B2 shares 76% and 73% amino acidsequence identity with mouse and rat Serpin B2, respectively.
 
全称：Plasminogen activator inhibitor 2 (SERPINB2)
 
说明书：待上传