Human FCGR3A Protein, Recombinant

产品货号：PR00899HuP1
   
$ 询价

规格：100ug

产品名称：Human FCGR3A Protein, Recombinant
 
纯度：≥95 % as determined by SDS-PAGE
 
内毒素：/
 
生物活性：/
 
序列起止：Gly17~Gln208
 
标签：C-His tag
 
Uniprot链接：P08637
 
表达系统：E.coli
 
种属：Human
 
预测 N 端：Met
 
预测分子量：/
 
缓冲液：20mM Tris, 250mM imidazole, 500mM NaCl, pH8.0, containing 10% glycerol.
 
运输方式：This Protein is shipped as lyophilized powder at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
稳定性 & 储存条件：Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
 
复溶：Please refer to COA for detailed information
 
别称：Fc-gamma RIII/Fc-gamma RIIIa/FcRIII/FcRIIIa/CD16A/FCG3/FCGR3/IGFR3
 
背景信息：Fc gamma RIIIA/CD16a. Fc gamma  RIIIA/CD16a is a low/intermediate affinity receptor for polyvalent immune-complexed IgG. It is involved in phagocytosis, secretion of enzymes and inflammatory mediators, antibody-dependent cytotoxicity, and clearance of immune complexes (1-3). In humans, it is expressed as a 50-70 kDa transmembrane activating receptor on NK cells, T cells, monocytes, and macrophages (2). It is closely related to the GPI-linked Fc gamma  RIIIB which is expressed on human neutrophils and eosinophils (1, 3). These two proteins share 97% amino acid (aa) identity within their extracellular domains (ECD) (4). The ECD of Fc gamma  RIIIA also shares 63%, 61%, 65%, 59%, and 58% aa identity with mouse Fc gamma  RIV, rat Fc gamma  RIIIA, feline CD16, bovine CD16, and porcine Fc gamma  RIIIB, respectively. Mature human Fc gamma  RIIIA consists of a 192 aa ECD with two C2-type Ig-like domains, a 21 aa transmembrane segment, and a 25 aa cytoplasmic domain. In humans, a single nucleotide polymorphism (T230A) creates high binding (176V) and low binding (176F) forms that may influence susceptibility to autoimmune diseases or response to therapeutic IgG antibodies (5, 6). Fc gamma  RIIIA surface expression requires interaction with an accessory chain, either the common  gamma -chain or CD3 zeta  (7, 8). Glycosylation patterns, electrophoretic mobility, and binding affinity appear to differ between NK cell and monocyte Fc gamma  RIIIA (9). Shed forms of both Fc gamma  RIIIA and Fc gamma  RIIIB can be generated by proteolytic cleavage and retain binding activity (10-13). Shedding from monocytes and macrophages can be triggered by cell activation or phagocytosis (13). Soluble Fc gamma  RIII circulates in normal plasma and is elevated in rheumatoid arthritis and in coronary artery diseases (11, 12).
 
全称：Low affinity immunoglobulin gamma Fc region receptor III-A (FCGR3A)
 
说明书：待上传