Human FGL2 Protein, Recombinant

产品货号：PR00904HuP1
   
$ 询价

规格：100ug

产品名称：Human FGL2 Protein, Recombinant
 
纯度：≥95 % as determined by SDS-PAGE
 
内毒素：/
 
生物活性：/
 
序列起止：Asn24~Pro439
 
标签：C-His tag
 
Uniprot链接：Q14314
 
表达系统：E.coli
 
种属：Human
 
预测 N 端：Met
 
预测分子量：/
 
缓冲液：20mM Tris, 250mM imidazole, 500mM NaCl, pH8.0, containing 10% glycerol.
 
运输方式：This Protein is shipped as lyophilized powder at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
稳定性 & 储存条件：Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
 
复溶：Please refer to COA for detailed information
 
别称：T49, PT49, Fibroleukin
 
背景信息：FGL2. FGL2 (fibrinogen-like protein 2), also called fibroleukin, is a 64-70kDa secreted glycoprotein of the Fibrinogen-like superfamily. It hasprothrombinase activity and also promotes T regulatory (Treg)activity (1-6). The human FGL2 gene encodes a 439 amino acid (aa)protein that contains a 23 aa signal sequence and a 416 aa maturesequence with a coiled-coil region and a fibronectin C-terminal homology domainor FRED (1, 2).  A 260-280 kDa FGL2 complex is thought to be atetramer formed by covalent disulfide linkage of dimers that are associated viacoiled-coil interactions (2, 3). Mature human FGL2 shares 79% aa identitywith mouse and rat FGL2. FGL2 appears to have two modes of action. One modeinvolves its prothrombinase activity, which requires calcium and acidicphospholipids (4). This mode is thought to be active during hepatitis viralinfections when FGL2, produced by macrophages in response to IFN-gamma, induceshepatic apoptosis and fibrin deposition (7). In addition, FGL2 produced byendothelial cells in response to TNF-alpha within cardiac xenografts orallografts promotes coagulation during acute vascular rejection (7-9). A secondmode of action involves soluble (not phospholipid-associated) FGL2 and isindependent of prothrombinase activity (2). Soluble FGL2 is required for Tregfunction, and directly suppresses DC, T, and B cell immune reactivity;consequently, some FGL2-deficent mice develop autoimmune glomerulonephritis (5, 6). In vitro, soluble FGL2 can skew T cell polarization towardTh2 and inhibit proliferation of stimulated T cells and maturation of DC(6). In pregnancy, fetal trophoblast cells secrete FGL2. The immune suppressivemode of FGL2 may prevent early fetal loss; however, the procoagulant mode isthought to mediate infection-triggered abortion (10). In the central nervoussystem (CNS), FGL2 was shown to be highly expressed in glioma stem cells andprimary glioblastoma cells and may serve as a critical immune oncology target(11).
 
全称：Fibroleukin (FGL2)
 
说明书：待上传