Human CKM Protein, Recombinant

产品货号：PR00011HuP1
   
$ 待定

规格     100μg

产品名称：Human CKM Protein, Recombinant
 
纯度：≥95 % as determined by SDS-PAGE
 
内毒素：/
 
生物活性：/
 
序列起止：Met1~Lys381
 
标签：N-His tag
 
Uniprot链接：P06732
 
表达系统：E.coli
 
种属：Human
 
预测 N 端：Met
 
预测分子量：41.91 kDa
 
缓冲液：20mM Tris, 250mM imidazole, 500mM NaCl, pH8.0, containing 10% glycerol.
 
运输方式：This Protein is shipped as lyophilized powder at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
稳定性 & 储存条件：Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
 
复溶：Please refer to COA for detailed information
 
别称：CK-MM, CKMM, CK3, CK-M, MM-CK, M-CK, Creatine kinase M-type, N-terminally processed
 
背景信息：Creatine Kinase MM/CKMM. Creatine kinase (CK) catalyzes the conversion of creatine to phosphocreatine (PCr) by consuming adenosine triphosphate (ATP) and generating adenosine diphosphate (ADP). CK reaction is reversible and thus ATP can be generated from PCr and ADP (1). In tissues and cells that consume ATP rapidly, especially skeletal muscle, but also brain, photoreceptor cells of the retina, hair cells of the inner ear, spermatozoa and smooth muscle, PCr serves as an energy reservoir for the rapid buffering and regeneration of ATP in situ, as well as for intracellular energy transport by the PCr shuttle or circuit (2). Clinically, creatine kinase is assayed in blood tests as a marker of myocardial infarction (heart attack), rhabdomyolysis (severe muscle breakdown), muscular dystrophy, autoimmune myositides and acute renal failure. Creatine kinase M (CKM), especially, is a cytoplasmic enzyme and is an important serum marker for myocardial infarction. It acts as a homodimer (MM type) in striated muscle as well as in other tissues, and forms a heterodimer (MB type) with CKB, a brain isozyme, in the heart (3). The recombinant human CKM is in the MM type and its activity is measured using a phosphatase-coupled method (4).
 
全称：Creatine kinase M-type (CKM)
 
说明书：待上传