Human IFNG Protein, Recombinant

产品货号：PR00017HuP1
   
$ 询价

规格   100ug
 

产品名称：Human IFNG Protein, Recombinant
 
纯度：≥95 % as determined by SDS-PAGE
 
内毒素：< 1.0 EU per μg of the protein as determined by the LAL method
 
生物活性：/
 
序列起止：Gln24~Gly161
 
标签：N-His tag
 
Uniprot链接：P01579
 
表达系统：E.coli
 
种属：Human
 
预测 N 端：Met
 
预测分子量：/
 
缓冲液：20mM Tris, 250mM imidazole, 500mM NaCl, pH8.0, containing 10% glycerol.
 
运输方式：This Protein is shipped as lyophilized powder at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
稳定性 & 储存条件：Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
 
复溶：Please refer to COA for detailed information
 
质量验证图：/

别称：IFN-G, IFG, IFI, INFr, IFN, Immune Interferon
 
背景信息：IFN-gamma. Interferon-gamma (IFN-gamma ), also known as type II or immune interferon, exerts a wide range of immunoregulatory activities and is considered to be the prototype proinflammatory cytokine (1, 2). Mature canine IFN-gamma  exists as a noncovalently linked homodimer of 20‑25 kDa variably glycosylated subunits (3). It shares 79%‑88% amino acid sequence identity with bovine, equine, and feline IFN-gamma, 62%‑73% with human, porcine, and rhesus IFN-gamma, and 40%-47% with cotton rat, mouse, and rat IFN-gamma. IFN-gamma  dimers bind to IFN-gamma  RI (alpha subunits) which then interact with IFN-gamma  RII (beta subunits) to form the functional receptor complex of two  alpha  and two  beta  subunits. Inclusion of IFN-gamma  RII increases the binding affinity for ligand and the efficiency of signal transduction (4, 5). IFN-gamma  is produced by a variety of immune cells under inflammatory conditions, notably by T cells and NK cells (6). It plays a key role in host defense by promoting the development and activation of Th1 cells, chemoattraction and activation of monocytes and macrophages, up‑regulation of antigen presentation molecules, and immunoglobulin class switching in B cells. It also exhibits antiviral, antiproliferative, and apoptotic effects (6, 7). In addition, IFN-gamma  functions as an anti-inflammatory mediator by promoting the development of regulatory T cells and inhibiting Th17 cell differentiation (8, 9). The pleiotropic effects of IFN-gamma  contribute to the development of multiple aspects of atherosclerosis (7).

全称：Interferon gamma (IFNG)
 
说明书：待上传