产品名称：Human BECN1 Protein, Recombinant
纯度：≥95 % as determined by SDS-PAGE
内毒素：/
生物活性：/
序列起止：Met1~450Lys
标签：N-His tag
Uniprot链接：Q14457
表达系统：E.coli
种属：Human
预测 N 端：Met
预测分子量：49.5 kDa
缓冲液：20mM Tris, 250mM imidazole, 500mM NaCl, pH8.0, containing 10% glycerol.
运输方式：This Protein is shipped as lyophilized powder at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
稳定性 & 储存条件：Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
复溶：Please refer to COA for detailed information
质量验证图：/
别称：ATG6, VPS30, Coiled-Coil,Myosin-Like BCL2 Interacting Protein, ATG6 Autophagy Related 6 Homolog
背景信息：Beclin 1, also known as ATG6 or VPS30, interacts with various cofactors (e.g. Ambra1, Barkor (Atg14), Rubicon, or UVRAG) to regulate the lipid kinase Vps34 and promote the formation of the BECLIN1-Vps34-Vps15 complex, hence inducing autophagy. Its function (via the BH3 domain) is inhibited by Bcl-2 or Bcl-XL. Beclin 1 (BECN1) is a crucial molecule in the control of the autophagic activity, and its activity is regulated by multiple mechanisms, including the post-translational modification, protein-protein interaction, and subcellular localization. It plays a role in crosstalk between apoptosis and autophagy. It has been reported that Beclin 1 can be cleaved into fragments of 50, 37 and 35 kDa during apoptosis. It is involved in many disorders, including neurodegeneration and cancer (tumorigenesis). Beclin 1 is a mammalian tumor suppressor, and its gene is monoallelically deleted in 75% of ovarian, 50% of breast, and 40% of prostate cancers. Decreased expression of Beclin 1 has also been observed in human brain and lung tumors. The level of Beclin 1 was decreased in the affected brain regions of patients with Alzheimers disease early in the disease process. Recent studies have also shown that gain and loss of Beclin 1 function affects the death of heart cells.
全称：Beclin-1 (BECN1)