Human SQSTM1 Protein, Recombinant

产品货号：PR00063HuP1
   
$ 询价

规格    100ug

产品名称：Human SQSTM1 Protein, Recombinant
 
纯度：≥95 % as determined by SDS-PAGE
 
内毒素：/
 
生物活性：/
 
序列起止：Val136~Gln400
 
标签：/
 
Uniprot链接：Q13501
 
表达系统：E.coli
 
种属：Human
 
预测 N 端：Met
 
预测分子量：/
 
缓冲液：20mM Tris, 250mM imidazole, 500mM NaCl, pH8.0, containing 10% glycerol.
 
运输方式：This Protein is shipped as lyophilized powder at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
稳定性 & 储存条件：Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
 
复溶：Please refer to COA for detailed information
 
质量验证图：/

别称：OSIL, PDB3, ZIP3, p62, p62B, p60, A170, Paget Disease Of Bone 3, Oxidative Stress Induced Like, EBI3-associated protein of 60 kDa, Ubiquitin-binding protein p62
 
背景信息：Sequestosome 1 (SQSTM1/p62) is a multifunctional adaptor protein implicated in selective autophagy, cell signaling pathways, and tumorigenesis. p62 has been implicated in shuttling ubiquitinated and aggregated proteins for autophagic degradation. p62 is degraded during the autophagic process, which makes its intracellular level a marker for autophagy progression. p62 is at the cross-roads of several signaling pathways including Ras/ Raf/ MAPK and NFκB and plays important role in cancer. p62 is a component of inclusion bodies/ protein aggregates found in human diseases, including Huntingtons disease, Alzheimers disease, Parkinsons disease, and nephropathic cystinosis (PMID: 22074114, 22860231, 22714671). The molecular weight of p62 is predicted to be 48/ 38 kDa (depending on the isoform), while western blot analyses using this antibody detects  the bands around 45-48 kDa and 60-62 kDa, respectively.

全称：Sequestosome-1 (SQSTM1)
 
说明书：待上传