Human CD68 Protein, Recombinant

产品货号：PR00065HuP1
   
$ 询价

规格    100ug

产品名称：Human CD68 Protein, Recombinant
 
纯度：≥95 % as determined by SDS-PAGE
 
内毒素：/
 
生物活性：/
 
序列起止：Asn22~Ser319
 
标签：/
 
Uniprot链接：P34810
 
表达系统：E.coli
 
种属：Human
 
预测 N 端：Met
 
预测分子量：/
 
缓冲液：20mM Tris, 250mM imidazole, 500mM NaCl, pH8.0, containing 10% glycerol.
 
运输方式：This Protein is shipped as lyophilized powder at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
稳定性 & 储存条件：Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
 
复溶：Please refer to COA for detailed information
 
质量验证图：/

别称：CD68, GP110, Macrosialin, Macrophage Antigen CD68
 
背景信息：CD68/SR-D1. CD68, also called Scavenger Receptor D1(SR-D1) and LAMP-4, is a heavily glycosylated type I transmembrane glycoproteinthat belongs to the LAMP family (1). Human CD68 contains 354 amino acids (aa), witha 21 aa signal sequence and a 298 aa extracellular domain (ECD), a 25 aatransmembrane domain, and a 10 aa cytoplasmic domain. The ECD of CD68 has 9 glycosylation sites and a mucin-like region in aa 23-140. Within the ECD, humanCD68 shares a 65% and 67% amino acid sequence identity with that of mouse andrat CD68, respectively. CD68 is expressed onmonocytes and tissue macrophages and serves as a scavenger receptor foroxidized LDL (2).  In contrast to other members of the LAMP-family ofglycoproteins which are ubiquitously expressed in all cell types, CD68 appearedto have a more restricted, cell-type specific pattern of expression (3 ,4). CD68 is alsoa biomarker of rheumatoid arthritis and Hodgkin's lymphoma (5, 6). CD68influences the functions of cells through NF-kB/focal adhesion kinase pathway (7).In addition, CD68 on macrophages binds tightly to both S100A8 and S100A9 toenhance the cell immunity (8).

全称：Macrosialin (CD68)
 
说明书：待上传