Human IL1B Protein, Recombinant

产品货号：PR00080HuP1
   
$ 询价

规格    100ug

产品名称：Human IL1B Protein, Recombinant
 
纯度：≥95 % as determined by SDS-PAGE
 
内毒素：/
 
生物活性：/
 
序列起止：Ala117~Ser269
 
标签：N-His tag
 
Uniprot链接：P01584
 
表达系统：E.coli
 
种属：Human
 
预测 N 端：Met
 
预测分子量：16.83 kDa
 
缓冲液：20mM Tris, 250mM imidazole, 500mM NaCl, pH8.0, containing 10% glycerol.
 
运输方式：This Protein is shipped as lyophilized powder at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
稳定性 & 储存条件：Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
 
复溶：Please refer to COA for detailed information
 
质量验证图：/

别称：IL1-B, IL1-Beta, IL1F2, IL-1β, Interleukin-1 Family Member 2, Catabolin
 
背景信息：IL-1 beta/IL-1F2. IL-1 is a name that designates two pleiotropic cytokines, IL-1 alpha  (IL-1F1) and IL-1 beta  (IL-1F2), which are the products of distinct genes. IL-1 alpha  and IL-1 beta  are structurally related polypeptides that share approximately 27% amino acid (aa) identity in equine. Both proteins are produced by a wide variety of cells in response to inflammatory agents, infections, or microbial endotoxins. While IL-1 alpha  and IL-1 beta  are regulated independently, they bind to the same receptor and exert identical biological effects. IL-1 RI binds directly to IL-1 alpha  or IL-1 beta  and then associates with IL-1 R accessory protein (IL-1 R3/IL-1 R AcP) to form a high-affinity receptor complex that is competent for signal transduction. IL-1 RII has high affinity for IL-1 beta  but functions as a decoy receptor and negative regulator of IL-1 beta  activity. IL-1ra functions as a competitive antagonist by preventing IL-1 alpha  and IL-1 beta  from interacting with IL-1 RI (1 - 4). The equine IL-1 beta  cDNA encodes a 268 aa precursor. A 115 aa propeptide is cleaved intracellularly by the cysteine protease IL-1 beta -converting enzyme (Caspase-1/ICE) to generate the active cytokine (5 - 7). An alternatively spliced form of equine IL-1 beta  has a deletion which encompasses the Caspase-1 cleavage site and potentially results in a membrane-associated form (8). The 17 kDa mature equine IL-1 beta  shares 65% - 75% aa sequence identity with canine, cotton rat, feline, human, mouse, porcine, rat, and rhesus IL-1 beta.

全称：Interleukin-1 beta (IL1B)
 
说明书：待上传