Human ERBB2 Protein, Recombinant

产品货号：PR00188HuP1
   
$ 询价

规格    100ug

产品名称：Human ERBB2 Protein, Recombinant
 
纯度：≥95 % as determined by SDS-PAGE
 
内毒素：/
 
生物活性：/
 
序列起止：Tyr343~Thr652
 
标签：C-His tag
 
Uniprot链接：P04626
 
表达系统：E.coli
 
种属：Human
 
预测 N 端：Met
 
预测分子量：33.99 kDa
 
缓冲液：20mM Tris, 250mM imidazole, 500mM NaCl, pH8.0, containing 10% glycerol.
 
运输方式：This Protein is shipped as lyophilized powder at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
稳定性 & 储存条件：Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
 
复溶：Please refer to COA for detailed information
 
质量验证图：/

别称：CD340, EGFR2, HER-2/neu, HER2, NEU, MLN 19, NGL, TKR1, p185, Epidermal Growth Factor Receptor 2, V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/Glioblastoma Derived Oncogene Homolog
 
背景信息：HER2, also known as ErbB2 and Neu, is a 185-kDa transmembrane glycoprotein that is a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine  kinases. It has no ligand binding domain of its own and therefore cannot bind growth  factors. However, it does bind tightly to other ligand-bound EGF receptor family  members to form a heterodimer, stabilizing ligand binding and enhancing kinase- mediated activation of downstream signalling pathways, such as those involving  mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Amplification  and/or overexpression of HER2 have been reported in numerous cancers, including  breast and ovarian tumors. HER2 is a therapeutic target for the treatment of breast  cancer and other carcinomas. 

全称：Receptor tyrosine-protein kinase erbB-2 (ERBB2)

 
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