Anti-PMS2 Antibody, Recombinant Antibody

产品编号：RMAP0A7M1
   
$ 询价

规格     100ug

产品名称：Anti-PMS2 Antibody, Recombinant Antibody
 
经验证的应用：IHC
 
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来源：Recombinant Antibody
 
纯化：Protein A purified
 
缓冲液：Supplied in PBS, 50% glycerol and less than 0.02% sodium azide, PH7.4
 
偶联物：Unconjugated
 
状态：Liquid
 
运输方式：This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
储存条件：This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
 
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背景信息：Postmeiotic segregation increased 2 (PMS2), also known as PMS1 protein homologue 2, is a DNA mismatch repair (MMR) protein. The PMS2 gene family members are found in clusters on chromosome 7. PMS2 is a 96 kDa mismatch repair protein closely related to MLH1, MLH3 and PMS1, which are homologs of the bacterial mutL gene. The PMS2 protein forms a heterodimer with the MLH1 protein which is then activated in the presence of ATP; this complex coordinates the binding of other proteins that repair DNA errors arising during cell preparation for cell division.The loss of PMS2 expression in tumors can be helpful in identifying hMLH1 mutation carriers and identifies their suitability for mutation analysis.PMS2 gene defects account for a small but significant proportion of colorectal cancers and for a substantial proportion of tumors with microsatellite instability.

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