Anti-Phospho-MEK1/2 (Ser217/221) Antibody, Recombinant Antibody

产品编号：RPTMB5A1
   
￥ 询价

规格     100ug
 

产品名称：Anti-Phospho-MEK1/2 (Ser217/221) Antibody, Recombinant Antibody
 
克隆号：/
 
抗体亚型：/
 
经验证的应用：WB/IP
 
交叉反应：Human, Mouse, Rat, Monkey
 
特异性：Recognizes Phospho-MEK1/2 (Ser217/221)

免疫原：Synthetic peptide
 
制备方法：/
 
来源：Recombinant Rabbit IgG
 
纯化：Protein A purified
 
缓冲液：Supplied in PBS, 50% glycerol and less than 0.02% sodium azide, PH7.4
 
偶联物：Unconjugated
 
状态：Liquid
 
运输方式：This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
储存条件：This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

别称：/
 
背景信息：MEK1 and MEK2, also called MAPK or Erk kinases, are dual-specificity protein kinases that function in a mitogen activated protein kinase cascade controlling cell growth and differentiation. Activation of MEK1 and MEK2 occurs through phosphorylation of two serine residues at positions 217 and 221, located in the activation loop of subdomain VIII, by Raf-like molecules. MEK1/2 is activated by a wide variety of growth factors and cytokines and also by membrane depolarization and calcium influx. Constitutively active forms of MEK1/2 are sufficient for the transformation of NIH/3T3 cells or the differentiation of PC-12 cells. MEK activates p44 and p42 MAP kinase by phosphorylating both threonine and tyrosine residues at sites located within the activation loop of kinase subdomain VIII.

全称：/
 
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