Anti-Phospho-Stat3 (Tyr705) Antibody, Recombinant Antibody

产品编号:RPTMB8A1
   
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询价

规格     100ug
 

产品名称Anti-Phospho-Stat3 (Tyr705) Antibody, Recombinant Antibody
 
克隆号/
 
抗体亚型/
 
经验证的应用WB/IP/IHC/ChIP/IF/F
 
交叉反应Human, Mouse, Rat, Monkey
 
特异性Recognizes Phospho-Stat3 (Tyr705)

免疫原Synthetic peptide
 
制备方法/
 
来源Recombinant Rabbit IgG
 
纯化Protein A purified
 
缓冲液Supplied in PBS, 50% glycerol and less than 0.02% sodium azide, PH7.4
 
偶联物Unconjugated
 
状态:Liquid
 
运输方式This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
储存条件This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

别称/
 
背景信息The Stat3 transcription factor is an important signaling molecule for many cytokines and growth factor receptors and is required for murine fetal development. Research studies have shown that Stat3 is constitutively activated in a number of human tumors and possesses oncogenic potential and anti-apoptotic activities. Stat3 is activated by phosphorylation at Tyr705, which induces dimerization, nuclear translocation, and DNA binding. Transcriptional activation seems to be regulated by phosphorylation at Ser727 through the MAPK or mTOR pathways. Stat3 isoform expression appears to reflect biological function as the relative expression levels of Stat3α (86 kDa) and Stat3β (79 kDa) depend on cell type, ligand exposure, or cell maturation stage. It is notable that Stat3β lacks the serine phosphorylation site within the carboxy-terminal transcriptional activation domain.

全称/
 
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