Anti-Phospho-SAPK/JNK (Thr183/Tyr185) Antibody, Recombinant Antibody

产品编号：RPTMB6A1
   
￥ 询价

规格     100ug
 

产品名称：Anti-Phospho-SAPK/JNK (Thr183/Tyr185) Antibody, Recombinant Antibody

克隆号：/
 
抗体亚型：/
 
经验证的应用：WB/IP/IHC
 
交叉反应：Human, Mouse, Rat, Fruitfly, Yeast
 
特异性：Recognizes Phospho-SAPK/JNK (Thr183/Tyr185)

免疫原：Synthetic peptide
 
制备方法：/
 
来源：Recombinant Rabbit IgG
 
纯化：Protein A purified
 
缓冲液：Supplied in PBS, 50% glycerol and less than 0.02% sodium azide, PH7.4
 
偶联物：Unconjugated
 
状态：Liquid
 
运输方式：This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
储存条件：This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

别称：/
 
背景信息：The stress-activated protein kinase/Jun-amino-terminal kinase SAPK/JNK is potently and preferentially activated by a variety of environmental stresses including UV and gamma radiation, ceramides, inflammatory cytokines, and in some instances, growth factors and GPCR agonists. As with the other MAPKs, the core signaling unit is composed of a MAPKKK, typically MEKK1-MEKK4, or by one of the mixed lineage kinases (MLKs), which phosphorylate and activate MKK4/7. Upon activation, MKKs phosphorylate and activate the SAPK/JNK kinase . Stress signals are delivered to this cascade by small GTPases of the Rho family (Rac, Rho, cdc42). Both Rac1 and cdc42 mediate the stimulation of MEKKs and MLKs. Alternatively, MKK4/7 can be activated in a GTPase-independent mechanism via stimulation of a germinal center kinase (GCK) family member. There are three SAPK/JNK genes each of which undergoes alternative splicing, resulting in numerous isoforms. SAPK/JNK, when active as a dimer, can translocate to the nucleus and regulate transcription through its effects on c-Jun, ATF-2, and other transcription factors.

全称：/
 
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