Anti-malonyllysine Antibody,  Recombinant Antibody,  R1

产品编号：RPTMD1M1-R1
   
￥ 询价

规格     100ug

浓度     1.3mg/ml

说明书

产品名称：Anti-malonyllysine Antibody,  Recombinant Antibody,  R1
 
克隆号：R1
 
抗体亚型：Mouse IgG2b
 
经验证的应用：WB
 
交叉反应：All
 
特异性：SUMO-1 Antibody detects recombinant SUMO-1 and endogenous levels of sumoylated proteins.

免疫原：Synthetic peptide
 
宿主：CHOS/293F
 
来源：Recombinant Mouse IgG
 
纯化：Protein A purified
 
缓冲液：Supplied in PBS, 50% glycerol and less than 0.02% sodium azide, PH7.4
 
状态：Liquid
 
应用：The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.       WB: 0.5~5ug/ml
 
使用&储存条件：Shipped at 4℃.Store at 4℃ for frequent use.Aliquot and store at -20℃ for 12 months.Avoid repeated freezing/thawing and violent shaking.Please centrifuge it, before using.

质量验证图：












别称：Kmal, Malonyl-Lysine, 丙二酰化
 
背景信息：Lysine is subject to a wide array of regulatory post-translational modifications due to its positively charged ε-amino group side chain. The most prevalent of these are ubiquitination and acetylation, which are highly conserved among prokaryotes and eukaryotes. Acyl group transfer from the metabolic intermediates acetyl-, succinyl-, malonyl-, glutaryl-, butyryl-, propionyl-, and crotonyl-CoA all neutralize lysine’s positive charge and confer structural alterations affecting substrate protein function. Lysine acetylation is catalyzed by histone acetyltransferases, HATs, using acetyl-CoA as a cofactor. Deacylation is mediated by histone deacetylases, HDACs 1-11, and NAD-dependent Sirtuins 1-7. Some sirtuins have little to no deacetylase activity, suggesting that they are better suited for other acyl lysine substrates.SIRT5 is a predominantly mitochondrial desuccinylase and demalonylase. In the absence of a known malonyltransferase, nonenzymatic protein malonylation is likely driven by the concentration of malonyl-CoA and intracellular pH and is subject to metabolic fluctuations. Malonylation is especially prevalent among mitochondrial metabolic proteins. In type II diabetes mouse models, notably elevated malonylation can be detected mainly, but not exclusively, on proteins of glucose and fatty acid metabolism. Yeast histone H3K56 malonylation suggests poor DNA binding efficiency and may lead to reduced cell viability.

全称：/