Anti-CRTC2 Antibody, Mouse Monoclonal, C5


产品编号：PM00058HuM10-C5
  
$ 询价

规格     50uL  100uL  200uL   可选

产品名称：Anti-CRTC2 Antibody, Mouse Monoclonal, C5

克隆号：C5
 
抗体亚型：
 
经验证的应用：WB/ICC
 
交叉反应：
 
特异性：human CRTC2

免疫原：Recombinant human CRTC2 protein, fragment Met1~Arg120; UniprotKB: Q53ET0
 
制备方法：Produced in rabbits immunized with human CRTC2, and purified by antigen affinity chromatography.
 
来源：Monoclonal Mouse IgG
 
纯化：Immunogen affinity purified
 
缓冲液：Supplied in PBS, 50% glycerol and less than 0.02% sodium azide, PH7.4
 
偶联物：Unconjugated
 
浓度：Liquid
 
运输方式：This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
储存条件：This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

图片：


Figure1.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human  lung   sections labelling CRTC2 with purified PM00058HuM10-C5 at 5ug/ml. Heat mediated antigen retrieval was performed using citrate buffer (pH 6.0).  Tissue was counterstained with Hematoxylin. Mouse specific IHC polymer detection kit HRP/DAB secondary antibody was used at 1/4000 dilution. PBS instead of the primary antibody was used as the negative control.




 
 
别称：TORC2, Transducer of CREB protein 2, Transducer of regulated cAMP response element-binding protein 2
 
背景信息：CRTC2, also named as TORC2, belongs to the TORC family. It is a transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. It acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 Ser-133 phosphorylation. CRTC2 enhances the interaction of CREB1 with TAF4. Ir regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. CRTC2 regulates the expression of specific genes such as the steroidogenic gene, StAR. TORC2 was recently shown to be an important regulator of gluconeogenesis in the livers of mammals. It is one of the other key regulators of CRE-dependent MIE gene expression in NT2 cells. This regulation is linked to VIP-induced TORC2 dephosphorylation and translocation to the nucleus. (PMID: 19369332, 20504934 ) .

全称：CREB-regulated transcription coactivator 2 (CRTC2)
 
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