Anti-ERBB2 Antibody, Rabbit Polyclonal

产品编号：PA00188HuA10
   
$ 询价

规格     50uL  100uL  200uL  可选

产品名称：Anti-ERBB2 Antibody, Rabbit Polyclonal
 
经验证的应用： WB

交叉反应：/
 
特异性：human ERBB2
 
免疫原：Recombinant human ERBB2 protein, fragment Tyr343~Thr652; UniprotKB: P04626
 
制备方法：Produced in rabbits immunized with human ERBB2, and purified by antigen affinity chromatography.
 
来源：Polyclonal Rabbit IgG
 
纯化：Immunogen affinity purified
 
缓冲液：Supplied in PBS, 50% glycerol and less than 0.02% sodium azide, PH7.4
 
偶联物：Unconjugated
 
状态：Liquid
 
运输方式：This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
储存条件：This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
 
别称：CD340, EGFR2, HER-2/neu, HER2, NEU, MLN 19, NGL, TKR1, p185, Epidermal Growth Factor Receptor 2, V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/Glioblastoma Derived Oncogene Homolog
 
背景信息：HER2, also known as ErbB2 and Neu, is a 185-kDa transmembrane glycoprotein that is a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine  kinases. It has no ligand binding domain of its own and therefore cannot bind growth  factors. However, it does bind tightly to other ligand-bound EGF receptor family  members to form a heterodimer, stabilizing ligand binding and enhancing kinase- mediated activation of downstream signalling pathways, such as those involving  mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Amplification  and/or overexpression of HER2 have been reported in numerous cancers, including  breast and ovarian tumors. HER2 is a therapeutic target for the treatment of breast  cancer and other carcinomas. This antibody raised against a synthesized peptide corresponding to 1237-1255aa of human HER2 recognizes the 185-kDa full-length glycosylated form and other lower molecular-mass forms of HER2, including the truncated form.

全称：Receptor tyrosine-protein kinase erbB-2 (ERBB2)
 
说明书：待上传