Anti-FASN Antibody, Rabbit Polyclonal

产品编号:PA00536HuA50
   
询价

规格     50uL  100uL  200uL  可选

产品名称Anti-FASN Antibody, Rabbit Polyclonal
 
经验证的应用:ICC
 
交叉反应/
 
特异性human FASN
 
免疫原Recombinant human FASN protein, fragment Val1864~Tyr2118; UniprotKB: P49327
 
制备方法Produced in rabbits immunized with human FASN, and purified by antigen affinity chromatography
 
来源Polyclonal Rabbit IgG
 
纯化Immunogen affinity purified
 
缓冲液Supplied in PBS, 50% glycerol and less than 0.02% sodium azide, PH7.4
 
偶联物Unconjugated
 
状态Liquid
 
运输方式This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
储存条件This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

图片:


Figure1.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human kidney cancer  sections labelling FASN with purified PA00536HuA50 at 10ug/ml. Heat mediated antigen retrieval was performed using EDTA buffer (pH 9.0).  Tissue was counterstained with Hematoxylin. Rabbit specific IHC polymer detection kit HRP/DAB secondary antibody was used at 1/4000 dilution. PBS instead of the primary antibody was used as the negative control. 




别称FAS, OA519, SDR27X1, Short Chain Dehydrogenase/Reductase Family 27X,Member 1, S-acetyltransferase, 3-oxoacyl synthase, Oleoyl hydrolase, Enoyl-acyl-carrier-protein reductase
 
背景信息FASN gene codes for an enzyme essential for de novo fatty acid synthesis and cellular substrate energy metabolism. Active FASN is a homodimer in which each peptide subunit has a molecular weight of 260 kDa. FASN is overexpressed in various types of cancer including glioblastomas and is a potential therapeutic target. Recently FASN has been reported to contribute to the neurogenesis since FASN mutation caused intellectual disability in mice
 
全称Fatty acid synthase (FASN)
 
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