Anti-MAD2L2 Antibody, Rabbit Polyclonal

产品编号:PA00223HuA10
   
询价

规格     50uL  100uL  200uL  可选
产品名称Anti-MAD2L2 Antibody, Rabbit Polyclonal
 
经验证的应用:WB/IHC/ICC

交叉反应:Hu
 
特异性human MAD2L2
 
免疫原Recombinant human MAD2L2 protein, fragment Met1~Ser211; UniprotKB: Q9UI95

制备方法Produced in rabbits immunized with human MAD2L2, and purified by antigen affinity chromatography.

来源Polyclonal Rabbit IgG
 
纯化Immunogen affinity purified
 
缓冲液Supplied in PBS, 50% glycerol and less than 0.02% sodium azide, PH7.4
 
偶联物Unconjugated
 
状态Liquid
 
运输方式This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
储存条件This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.







Figure1.Western blot analysis of extracts of various cell lines and tissue, using MAD2L2 antibody (PA00223HuA10) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L)  at 1:10000 dilution. 




别称MAD2B/REV7

背景信息MAD family, together with BUB and Mps1,Cdc20k, play roles in the mitotic spindle checkpoint. MAD2L2 is one of the MAD family. It can mediate the second polymerase switching in translation DNA synthesis by mediating the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1. Through regulation of the JNK-mediate phosphorylation and activation of the transcriptional activator ELK1, MAD2L2 involves in cellular response to DNA damage. Also it has role in the progression of cell cycle and peithelial-mesenchymal transdifferentiation.

全称:Mitotic spindle assembly checkpoint protein MAD2B (MAD2L2)

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