Anti-DICER1 Antibody, Rabbit Polyclonal
产品编号：PA00249HuA10
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规格 50uL 100uL 200uL 可选
产品名称：Anti-DICER1 Antibody, Rabbit Polyclonal
经验证的应用：WB/IHC/ICC
交叉反应：/
特异性：human DICER1
免疫原：Recombinant human DICER1 protein, fragment Asp256~Asp602; UniprotKB: Q9UPY3
制备方法：Produced in rabbits immunized with human DICER1, and purified by antigen affinity chromatography.
来源：Polyclonal Rabbit IgG
纯化：Immunogen affinity purified
缓冲液：Supplied in PBS, 50% glycerol and less than 0.02% sodium azide, PH7.4
偶联物：Unconjugated
状态：Liquid
运输方式：This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
储存条件：This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
别称：Dicer, HERNA, Dicer 1,Double-Stranded RNA-Specific Endoribonuclease, Helicase with RNase motif, Helicase MOI
背景信息：DICER1, also named as DICER, HERNA and KIAA0928, belongs to the helicase family and Dicer subfamily. It is required for formation of the RNA induced silencing complex (RISC). DICER1 is a component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. DICER1 cleaves double-stranded RNA to produce short interfering RNAs (siRNAs) which target the selective destruction of complementary RNAs. The antibody is specific to DICER1. The calcualted molecular weight of DICER1 is 219 kDa, but modified DICER1 is about 220-250 kDa. DICER1 exists some isoforms with molecular weight 219 kDa and 93 kDa.
全称：Endoribonuclease Dicer (DICER1)
说明书：待上传