Anti-IFNA1 Antibody, Rabbit Polyclonal

产品编号：PA00016HuA10
   
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规格     50uL  100uL  200uL

产品名称：Anti-IFNA1 Antibody, Rabbit Polyclonal

经验证的应用：WB/ICC
 
交叉反应：/
 
特异性：human IFNA1
 
免疫原：Recombinant human IFNA1 protein, fragment Cys24~Glu189; UniprotKB: P01562
 
制备方法：Produced in rabbits immunized with human IFNA1, and purified by antigen affinity chromatography.
 
来源：Polyclonal Rabbit IgG
 
纯化：Immunogen affinity purified
 
缓冲液：Supplied in PBS, 50% glycerol and less than 0.02% sodium azide, PH7.4
 
偶联物：Unconjugated
 
状态：Liquid
 
运输方式：This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
储存条件：This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
 
别称：IFNA1, IFL, LeIF D, IFN, IFN-Alpha, IFNA13, IFN-A, IFNAP22, IFN-Alpha 1b, Interferon Alpha 1b, Interferon, Leukocytic, IFN, Leukocyte, Interferon alpha-D
 
背景信息：IFN-alpha 1. Theinterferons (IFN) are a family of cytokines with potent antiviral,antiproliferative and immunomodulatory properties, and classified based ontheir binding specificity to cell surface receptors (1). The type I IFNbind to the interferon alpha receptor (IFNAR), which consists of two subunits:IFNAR1 ( alpha -subunit) and IFNAR2 ( beta -subunit). This binding contributes toTNF-alpha induced signaling (2, 3). Both the human and mouse genome code for more than a dozen closely related IFNa subtypes and the varous IFN a share about 80% sequence homology among them (4-5). Interferon-alpha 1 (IFNA1) is asecreted, approximately 19 kDa member of the type I interferon family ofmolecules (6). Mature mouse IFN-alpha 1 shares 63% and 82% amino acid sequenceidentity with human and rat IFN-alpha 1, respectively. Low level IFN-alpha is detectedunder physiological conditions, and the production of IFNs is markedly enhancedduring virus infection (7).  Althoughoriginally discovered by its capability to fight virusreplication, IFN-alpha functions as a prototypic tumorsuppressor that represses the clinical tumorigenic phenotype in somemalignancies (7).
 
全称：Interferon alpha-1/13 (IFNA1)
 
说明书：待上传