Anti-IFNG Antibody, Mouse Monoclonal

产品编号：PA00017RaA10
   
$ 询价

规格     50uL  100uL  200uL

产品名称：Anti-IFNG Antibody, Mouse Monoclonal

经验证的应用：/
 
交叉反应：/
 
特异性：rat IFNG
 
免疫原：Recombinant rat IFNG protein, fragment Gln23~Cys156; UniprotKB: P01581
 
制备方法：Produced in rabbits immunized with rat IFNG, and purified by antigen affinity chromatography.
 
来源：Polyclonal Rabbit IgG
 
纯化：Immunogen affinity purified
 
缓冲液：Supplied in PBS, 50% glycerol and less than 0.02% sodium azide, PH7.4
 
偶联物：Unconjugated
 
状态：Liquid
 
运输方式：This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
储存条件：This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
 
别称：IFN-G, IFG, IFI, INFr, IFN, Immune Interferon
 
背景信息：IFN-gamma. Interferon-gamma (IFN-gamma ), also known as type II or immune interferon, exerts a wide range of immunoregulatory activities and is considered to be the prototype proinflammatory cytokine (1, 2). Mature canine IFN-gamma  exists as a noncovalently linked homodimer of 20‑25 kDa variably glycosylated subunits (3). It shares 79%‑88% amino acid sequence identity with bovine, equine, and feline IFN-gamma, 62%‑73% with human, porcine, and rhesus IFN-gamma, and 40%-47% with cotton rat, mouse, and rat IFN-gamma. IFN-gamma  dimers bind to IFN-gamma  RI (alpha subunits) which then interact with IFN-gamma  RII (beta subunits) to form the functional receptor complex of two  alpha  and two  beta  subunits. Inclusion of IFN-gamma  RII increases the binding affinity for ligand and the efficiency of signal transduction (4, 5). IFN-gamma  is produced by a variety of immune cells under inflammatory conditions, notably by T cells and NK cells (6). It plays a key role in host defense by promoting the development and activation of Th1 cells, chemoattraction and activation of monocytes and macrophages, up‑regulation of antigen presentation molecules, and immunoglobulin class switching in B cells. It also exhibits antiviral, antiproliferative, and apoptotic effects (6, 7). In addition, IFN-gamma  functions as an anti-inflammatory mediator by promoting the development of regulatory T cells and inhibiting Th17 cell differentiation (8, 9). The pleiotropic effects of IFN-gamma  contribute to the development of multiple aspects of atherosclerosis (7).
 
全称：Interferon gamma (IFNG)
 
说明书：待上传