Anti-IL2 Antibody, Rabbit Polyclonal

产品编号：PA00020RaA10
   
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规格     50uL  100uL  200uL

产品名称：Anti-IL2 Antibody, Rabbit Polyclonal

经验证的应用：/
 
交叉反应：/
 
特异性：rat IL2
 
免疫原：Recombinant rat IL2 protein, fragment Ala21~Gln155; UniprotKB: P17108
 
制备方法：Produced in rabbits immunized with rat IL2, and purified by antigen affinity chromatography.
来源：Polyclonal Rabbit IgG
 
纯化：Immunogen affinity purified
 
缓冲液：Supplied in PBS, 50% glycerol and less than 0.02% sodium azide, PH7.4
 
偶联物：Unconjugated
 
状态：Liquid
 
运输方式：This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
储存条件：This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
 
别称：TCGF, Lymphokine, T-Cell Growth Factor, Aldesleukin
 
背景信息：IL-2. Bovine Interleukin-2 (IL-2) is a 15 kDa,  alpha -helical, single chain, potentially glycosylated polypeptide that has potent stimulatory activity for antigen-activated T cells (1 - 5). The molecule is synthesized as a 155 amino acid (aa) precursor that contains a 20 aa signal peptide plus a 135 aa mature segment that is possibly O-glycosylated (4, 5). The mature region has multiple  alpha -helices and one intrachain disulfide bond. Mature bovine IL-2 is 64%, 60%, 49%, 50%, 72%, 63% and 67% to mature human, canine, mouse, rat, porcine, equine, and feline IL-2, respectively. Mammalian cells known to express IL-2 include CD4+ and CD8+ T cells, visceral smooth muscle cells, eosinophils,  gamma δ T cells, B cells and dendritic cells. The receptor for IL-2 is complex and consists of three distinct subunits in varying combinations (6, 7). Two of these are ligand-binding and are termed IL-2 R alpha  and IL-2 R beta. IL-2 R alpha  is 55 kDa and binds IL-2 with low affinity. IL-2 R beta  is 75 kDa and binds IL-2 with intermediate affinity. Signal transduction is performed by both IL-2 R beta  and a 64 kDa common gamma chain ( gamma c). This signal transducing common gamma chain does not bind IL-2, but does heterodimerize with IL-2 R beta  to form a functional IL-2 receptor. The complex heterotrimeric  alpha -beta -gamma c receptor may arise from IL-2 binding to preformed R alpha -R beta  complexes (8). Functionally, IL-2 is best known for its autocrine and paracrine activity on T cells. It drives resting T cells into active G1, inducing IL-2 and IL-2 R alpha  synthesis and cell proliferation (7). It also promotes Fas-induced death of naïve CD4+ T cells, while having minimal effect on activated CD4+ memory lymphocytes. Finally, IL-2 seems to play a central role in the expansion and maintenance of CD4+ CD25+ regulatory T cells. Thus, IL-2 may be a key cytokine in the natural suppression of autoimmunity (9, 10).
 
全称：Interleukin-2 (IL2)
 
说明书：待上传