Anti-TNFRSF1B Antibody, Rabbit Polyclonal

产品编号：PA00583HuA10
   
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规格     50uL  100uL  200uL  可选

产品名称：Anti-TNFRSF1B Antibody, Rabbit Polyclonal
 
经验证的应用：WB/IHC
 
交叉反应：/
 
特异性：human TNFRSF1B
 
免疫原：Recombinant human TNFRSF1B protein, fragment Leu23~Asp257; UniprotKB: P20333
 
制备方法：Produced in rabbits immunized with human TNFRSF1B, and purified by antigen affinity chromatography
 
来源：Polyclonal Rabbit IgG
 
纯化：Immunogen affinity purified
 
缓冲液：Supplied in PBS, 50% glycerol and less than 0.02% sodium azide, PH7.4
 
偶联物：Unconjugated
 
状态：Liquid
 
运输方式：This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
储存条件：This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
 
别称：CD120B, P75, TBPII, TNF-R-II, TNF-R75, TNFBR, TNFR2, TNFR80, P75tnfr, Tumor necrosis factor receptor 2, p80 TNF-alpha receptor, Etanercept
 
背景信息：TNF RII/TNFRSF1B. Two types of soluble TNF receptors have beenidentified in human serum and urine which can neutralize the biological activitiesof TNF-alpha and TNF-beta (1, 2). These binding proteins represent truncatedforms of the two types of high-affinity cell surface receptors for TNF(TNFR-p60 Type B and TNFR-p80 Type A). Soluble TNF RII corresponds to TNFR-p80Type A (3). In the new TNF superfamily nomenclature, TNF RII is referred to asTNFRSF1B. These apparent soluble forms of the receptors appear to arise as aresult of shedding of the extracellular domains of the membrane-boundreceptors. Normal concentrations as high as 4 ng/mL are found in the serum ofhealthy individuals, and even higher levels may be found in some pathologicalconditions (4). Mature mouse TNF RII contains an extracellular domain (ECD, aa23 - 258) containing ten disulfide bonds, a transmembrane domain (aa 259-288),and a cytoplasmic domain (aa 289-474). Within the ECD, the mouse TNF RIIshares 57% and 84% aa sequence identity tohuman and rat TNF RII. TNF RII is expressed predominantly on cells of the hematopoietic lineage, such as T and natural killer cells, as well as on endothelial cells, microglia,astrocytes, neurons, oligodendrocytes, cardiac myocytes, and thymocytes (5-7). TNF RII activation primarily initiates pro-inflammatory and pro-survivalresponses via NF kappa B-dependent signaling pathways (5, 8). However, undercertain conditions, TNF RII signaling can induce apoptosis (5). Soluble TNF RIIis believed to inhibit TNF biological activity by binding TNF therebypreventing it from activating membrane TNF receptors (9)
 
全称：Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B)
 
说明书：待上传