Anti-BMP4 Antibody, Rabbit Polyclonal

产品编号：PA00639HuA10
   
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规格     50uL  100uL  200uL  可选

产品名称：Anti-BMP4 Antibody, Rabbit Polyclonal
 
经验证的应用：WB
 
交叉反应：/
 
特异性：human BMP4
 
免疫原：Recombinant human BMP4 protein, fragment Ser293~Arg408; UniprotKB: Q53XC5& P12644
 
制备方法：Produced in rabbits immunized with human BMP4, and purified by antigen affinity chromatography
 
来源：Polyclonal Rabbit IgG
 
纯化：Immunogen affinity purified
 
缓冲液：Supplied in PBS, 50% glycerol and less than 0.02% sodium azide, PH7.4
 
偶联物：Unconjugated
 
状态：Liquid
 
运输方式：This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
储存条件：This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
 
别称：BMP4
 
背景信息：BMP-4. Bonemorphogenetic protein 4 (BMP-4) is a TGF-beta superfamily ligand that is widelyexpressed from early embryogenesis through adulthood. It plays an importantrole in mesenchyme formation, epidermal determination, suppression of neuralinduction, the development of multiple organs, and tissue repair (1-5). It isan integral part of many stem cell differentiation pathways, including lungtissue, (6), adipogenesis (7) and osteogenesis (8, 9). The human BMP-4 precursorcontains a 273 amino acid (aa) propeptide and a 116 amino acid (aa) mature protein (10). Processingof the propeptide by furin or proprotein convertase 6 enables the formation ofthe mature disulfide-linked homodimeric BMP-4 and facilitates its secretion.Similar intracellular processes may lead to the formation and recreation ofBMP4/BMP7 disulfide-linked heterodimer (11-13). Mature human and mouse BMP-4share 98% aa sequence identity. Human BMP-4 shares 85% aa sequence identitywith human BMP-2 and less than 50% with other human BMPs. In Xenopus, BMP-4dimers provide ventralizing signals for existing mesoderm (14). BMP-4 signalsthrough tetrameric complexes composed of type I (primarily Activin RIA orBMPR-IA) and type II (primarily Activin RIIA or BMPR-II) receptors (15, 16). Thebioavailability of BMP-4 is regulated by its interaction with multiple proteinsand glycosaminoglycans (17-19)
 
全称：Bone morphogenetic protein 4 (BMP4)
 
说明书：待上传