Anti-TIMP4 Antibody, Rabbit Polyclonal

产品编号：PA00658HuA10
   
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规格     50uL  100uL  200uL  可选

产品名称：Anti-TIMP4 Antibody, Rabbit Polyclonal
 
经验证的应用：/
 
交叉反应：/
 
特异性：human TIMP4
 
免疫原：Recombinant human TIMP4 protein, fragment Cys30~Pro224; UniprotKB: Q99727
 
制备方法：Produced in rabbits immunized with human TIMP4, and purified by antigen affinity chromatography
 
来源：Polyclonal Rabbit IgG
 
纯化：Immunogen affinity purified
 
缓冲液：Supplied in PBS, 50% glycerol and less than 0.02% sodium azide, PH7.4
 
偶联物：Unconjugated
 
状态：Liquid
 
运输方式：This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
储存条件：This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
 
别称：TIMP Metallopeptidase Inhibitor 4, Tissue Inhibitor of Metalloproteinases 4
 
背景信息：TIMP-4. Tissue inhibitors of metalloproteinases (TIMPs) are a family of secreted proteins that regulate the activation and proteolytic activity of the zinc enzymes known as matrix metalloproteinases (MMPs). There are four known members of the family, TIMP-1, -2, -3 and -4. TIMP-4 is produced by a wide range of tissues, particularly brain, heart, ovary and skeletal muscle (1, 2). Limited studies have shown that TIMP-4 has a tumor suppressive effect against Wilm’s tumor, exhibits negative correlation with glioma maligancy and is found in breast carcinoma cells (3-5). TIMP-4 inhibits MMP-mediated proteolysis by forming a non-covalent binary complex with the MMP active site through its N-terminal domain. In addition, it binds to the hemopexin-like domain of pro-MMP-2 through its C-terminal domain in a manner similar to TIMP-2 (6). However, unlike TIMP-2, TIMP-4 does not promote pro-MMP-2 activation by MT1-MMP (MMP-14) (7). Although TIMP-4 is a potent inhibitor of most MMPs, it is not an effective inhibitor of ADAMs, such as TACE (8, 9)
 
全称：Metalloproteinase inhibitor 4 (TIMP4)
 
说明书：待上传