Anti-UCHL1 Antibody, Rabbit Polyclonal

产品编号：PA00283HuA10
   
$ 询价

规格     50uL  100uL  200uL  可选

产品名称：Anti-UCHL1 Antibody, Rabbit Polyclonal
 
经验证的应用：WB/ICC

交叉反应：/
 
特异性：human UCHL1

免疫原：Recombinant human UCHL1 protein, fragment Met1~Cys220; UniprotKB: P09936

制备方法：Produced in rabbits immunized with human UCHL1, and purified by antigen affinity chromatography.

来源：Polyclonal Rabbit IgG
 
纯化：Immunogen affinity purified
 
缓冲液：Supplied in PBS, 50% glycerol and less than 0.02% sodium azide, PH7.4
 
偶联物：Unconjugated
 
状态：Liquid
 
运输方式：This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
储存条件：This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

图片：

别称：PARK5, PGP9.5, Uch-L1, Neuron cytoplasmic protein 9.5, Ubiquitin thioesterase L1, Ubiquitin carboxyl-terminal hydrolase isozyme L1

背景信息：UCH-L1/PGP9.5. Deubiquitination is a critical regulatory process in the ubiquitin-proteasome pathway (1). Ubiquitin C-terminal hydrolases (UCHs) are a family of cysteine proteases that catalyze the hydrolysis of a peptide bond at the C-terminal glycine of ubiquitin. Members of the UCH family have been implicated in a number of human diseases, including neurodegenerative diseases and cancers (2). Mutations of the UCH-L1 gene and alterations of the protein activity have been found to be associated with several neurodegenerative disorders, including Parkinson’s, Huntington’s and Alzheimer’s diseases (3).  It is also implicated in cancer tumorigenesis, including lung, breast, liver, kidney, colorectal and ovarian cancers (4-8). UCH-L1 is thought to be a tumor suppressor and biomarker for hepatocellular carcinoma and other digestive tumors.

全称：Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL1)

说明书：

说明书