Anti-TGFB3 Antibody, Rabbit Polyclonal

产品编号：PA00785HuA10
   
$ 询价

规格     50uL  100uL  200uL

产品名称：Anti-TGFB3 Antibody, Rabbit Polyclonal

经验证的应用：WB
 
交叉反应：/
 
特异性：human TGFB3
 
免疫原：Recombinant human TGFB3 protein, fragment Ala301~Ser412(Tyr340Phe); UniprotKB: P10600
 
制备方法：Produced in rabbits immunized with human TGFB3, and purified by antigen affinity chromatography.

来源：Polyclonal Rabbit IgG
 
纯化：Immunogen affinity purified
 
缓冲液：Supplied in PBS, 50% glycerol and less than 0.02% sodium azide, PH7.4
 
偶联物：Unconjugated
 
状态：Liquid
 
运输方式：This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
储存条件：This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
 
别称：TGF-B3, LAP, Latency-associated peptide
 
背景信息：TGF-beta 3. TGF­-beta 3 (transforming growth factor-beta 3) is a member of a TGF­-beta  superfamily subgroup that is defined by their structural and functional similarities (1-5). TGF-beta 3 and its closely related proteins, TGF-beta 1 and ­ beta 2, act as cellular switches to regulate immune function, cell proliferation, and epithelial-­mesenchymal transition (4, 6, 7). The non-redundant biological effects of TGF-­ beta 3 include involvement in palatogenesis, chondrogenesis, and pulmonary development (1, 2, 7-9). Human TGF­-beta 3 cDNA encodes a 412 amino acid (aa) precursor that contains a 20 aa signal peptide and a 392 aa proprotein. The proprotein is processed by a furin-­like convertase to generate a 220 aa latency-­associated peptide (LAP) and a 112 aa mature TGF­-beta 3 (10, 11). Mature human TGF-­ beta 3 shows 100%, 99%, and 98% aa identity with mouse/dog/horse, rat, and pig TGF-­ beta 3, respectively. TGF-beta 3 is secreted as a latent complex. This latent form of TGF-beta 3 is activated by integrins, thrombospondin-1, plasmin, and matrix metalloproteases (12, 13). It can also be activated by extreme pH and reactive oxygen species (1-5, 12). TGF-beta 3 binds with high affinity to TGF-beta  RII, a type II serine/threonine kinase receptor. This receptor then phosphorylates and activates type I serine/threonine kinase receptors, TGF-­ beta  RI or ALK-­1, to modulate transcription through Smad phosphorylation (14-16). The divergent biological effects exerted by individual TGF-beta  isoforms is dependent upon the recruitment of co-receptors (TGF-­ beta  RIII and endoglin) and the subsequent initiation of Smad­-dependent or -independent signaling pathways (15, 17, 18).
 
全称：Transforming growth factor beta-3 proprotein [Cleaved into: Latency-associated peptide (TGFB3)
 
说明书：待上传