Anti-KDR Antibody, Rabbit Polyclonal

产品编号：PA00295HuA10
   
$ 询价

规格     50uL  100uL  200uL

产品名称：Anti-KDR Antibody, Rabbit Polyclonal

经验证的应用：/
 
交叉反应：/
 
特异性：human KDR
 
免疫原：Recombinant human KDR protein, fragment Asn46~Thr320; UniprotKB: P35968

制备方法：Produced in rabbits immunized with human KDR, and purified by antigen affinity chromatography.

来源：Polyclonal Rabbit IgG
 
纯化：Immunogen affinity purified
 
缓冲液：Supplied in PBS, 50% glycerol and less than 0.02% sodium azide, PH7.4
 
偶联物：Unconjugated
 
状态：Liquid
 
运输方式：This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
储存条件：This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

图片：


Figure1.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human  skin sections labelling KDR with purified PA00295HuA10 at 10ug/ml. Heat mediated antigen retrieval was performed using citrate buffer (pH 6.0).  Tissue was counterstained with Hematoxylin. Rabbit specific IHC polymer detection kit HRP/DAB secondary antibody was used at 1/4000 dilution. PBS instead of the primary antibody was used as the negative control.



 



Figure2.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human  kidney  sections labelling KDR with purified PA00295HuA10 at 10ug/ml. Heat mediated antigen retrieval was performed using citrate buffer (pH 6.0).  Tissue was counterstained with Hematoxylin. Rabbit specific IHC polymer detection kit HRP/DAB secondary antibody was used at 1/4000 dilution. PBS instead of the primary antibody was used as the negative control.


 
别称：CD309, FLK1, VEGFR, KDR, A Type III Receptor Tyrosine Kinase, Kinase Insert Domain Receptor, Kinase Insert Domain Receptor, Fetal Liver Kinase-1
 
背景信息：VEGFR2/KDR/Flk-1. VEGFR2 (KDR/Flk-1), VEGFR1 (Flt-1) and VEGFR3 (Flt-4) belong to the class III subfamily of receptor tyrosine kinases (RTKs). All three receptors contain seven immunoglobulin-like repeats in their extracellular domains and kinase insert domains in their intracellular regions. The expression of VEGFR1, 2, and 3 is almost exclusively restricted to the endothelial cells. These receptors are likely to play essential roles in vasculogenesis and angiogenesis. Mouse VEGFR2 cDNA encodes a 1367 amino acid (aa) residue precursor protein with a 19 aa residue signal peptide. Mature VEGFR2 is composed of a 743 aa residue extracellular domain, a 22 aa residue transmembrane domain and a 583 aa residue cytoplasmic domain. In contrast to VEGFR1 which binds both PlGF and VEGF with high affinity, VEGFR2 binds VEGF but not PlGF with high affinity. The recombinant soluble VEGFR2 Fc Chimera binds VEGF with high affinity and is a potent VEGF antagonist.
 
全称：Vascular endothelial growth factor receptor 2 (KDR)
 
说明书：待上传