Anti-AKT1 Antibody, Rabbit Polyclonal

产品编号:PA00320HuA10
   
询价

规格     50uL  100uL  200uL
产品名称Anti-AKT1 Antibody, Rabbit Polyclonal

经验证的应用WB/ICC
 
交叉反应Hu/Mu
 
特异性human AKT1
 
免疫原Recombinant human AKT1 protein, fragment Ser122~Thrhr443; UniprotKB: P31749

制备方法Produced in rabbits immunized with human AKT1, and purified by antigen affinity chromatography.

来源Polyclonal Rabbit IgG
 
纯化Immunogen affinity purified
 
缓冲液Supplied in PBS, 50% glycerol and less than 0.02% sodium azide, PH7.4
 
偶联物Unconjugated
 
状态Liquid
 
运输方式This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
储存条件This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

图片:








Figure1.Western blot analysis of extracts of various cell lines and tissue, using AKT1 antibody (PA00320HuA10) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L)  at 1:10000 dilution. 






别称AKT1, AKT, PKB-A, Proto-oncogene c-Akt, RAC-Alpha Serine/Threonine-Protein Kinase, V-akt Murine Thymoma Viral Oncogene Homolog 1
 
背景信息The serine-threonine protein kinase AKT1 is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery.

全称RAC-alpha serine/threonine-protein kinase (AKT1)
 
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