Anti-SERPINB2 Antibody, Rabbit Polyclonal

产品编号：PA00846HuA10
   
$ 询价

规格     50uL  100uL  200uL

产品名称：Anti-SERPINB2 Antibody, Rabbit Polyclonal

经验证的应用：WB
 
交叉反应：/
 
特异性：human SERPINB2
 
免疫原：Recombinant human SERPINB2 protein, fragment Glu2~Ala65; UniprotKB: P05120
 
制备方法：Produced in rabbits immunized with human SERPINB2, and purified by antigen affinity chromatography.

来源：Polyclonal Rabbit IgG
 
纯化：Immunogen affinity purified
 
缓冲液：Supplied in PBS, 50% glycerol and less than 0.02% sodium azide, PH7.4
 
偶联物：Unconjugated
 
状态：Liquid
 
运输方式：This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
储存条件：This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
 
别称：SERPINB2, PLANH2, Serpin Peptidase Inhibitor Clade B Member 2, Monocyte Arg-serpin, Placental plasminogen activator inhibitor, Serpin B2, Urokinase inhibitor
 
背景信息：Serpin B2. Serpin B2, also known as PAI-2, is an approximately60 kDa serine protease inhibitor (1). It is primarily secreted by macrophagesand monocytes (2, 3) and can form disulfide-linked multimers (4, 5). Serpin B2inhibits both the urokinase-type and tissue-type plasminogen activators (uPAand tPA) (3, 4, 6). Serpin B2 also promotes the clearance of uPA by enhancingits binding and uptake by LRP (7). It limits fibril formation by Huntingtonprotein (HTT) and beta-Amyloid peptides (8). It promotes Th2 biased immuneresponses and is important for intestinal CCL2 production, monocyte recruitment,and nematode clearance (2, 9). A non-glycosylated form of Serpin B2 is retainedintracellularly where it interferes with TNF-a inducedapoptosis by protecting the Retinoblastoma protein (RB1) from calpain digestion(10). It also inhibits proteasome activity in activated endothelial cells (11).Serpin B2 is upregulated in HIV-1 infected PBMC, induces RB1 upregulation, andpromotes HIV-1 replication (12). Human Serpin B2 shares 76% and 73% amino acidsequence identity with mouse and rat Serpin B2, respectively.
 
全称：Plasminogen activator inhibitor 2 (SERPINB2)
 
说明书：待上传