Anti-FCGR3A Antibody, Rabbit Polyclonal

产品编号：PA00899HuA10
   
$ 询价

规格     50uL  100uL  200uL

产品名称：Anti-FCGR3A Antibody, Rabbit Polyclonal

经验证的应用：/
 
交叉反应：/
 
特异性：human FCGR3A
 
免疫原：Recombinant human FCGR3A protein, fragment Gly17~Gln208; UniprotKB: P08637
 
制备方法：Produced in rabbits immunized with human FCGR3A, and purified by antigen affinity chromatography.

来源：Polyclonal Rabbit IgG
 
纯化：Immunogen affinity purified
 
缓冲液：Supplied in PBS, 50% glycerol and less than 0.02% sodium azide, PH7.4
 
偶联物：Unconjugated
 
状态：Liquid
 
运输方式：This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
储存条件：This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
 
别称：Fc-gamma RIII/Fc-gamma RIIIa/FcRIII/FcRIIIa/CD16A/FCG3/FCGR3/IGFR3
 
背景信息：Fc gamma RIIIA/CD16a. Fc gamma  RIIIA/CD16a is a low/intermediate affinity receptor for polyvalent immune-complexed IgG. It is involved in phagocytosis, secretion of enzymes and inflammatory mediators, antibody-dependent cytotoxicity, and clearance of immune complexes (1-3). In humans, it is expressed as a 50-70 kDa transmembrane activating receptor on NK cells, T cells, monocytes, and macrophages (2). It is closely related to the GPI-linked Fc gamma  RIIIB which is expressed on human neutrophils and eosinophils (1, 3). These two proteins share 97% amino acid (aa) identity within their extracellular domains (ECD) (4). The ECD of Fc gamma  RIIIA also shares 63%, 61%, 65%, 59%, and 58% aa identity with mouse Fc gamma  RIV, rat Fc gamma  RIIIA, feline CD16, bovine CD16, and porcine Fc gamma  RIIIB, respectively. Mature human Fc gamma  RIIIA consists of a 192 aa ECD with two C2-type Ig-like domains, a 21 aa transmembrane segment, and a 25 aa cytoplasmic domain. In humans, a single nucleotide polymorphism (T230A) creates high binding (176V) and low binding (176F) forms that may influence susceptibility to autoimmune diseases or response to therapeutic IgG antibodies (5, 6). Fc gamma  RIIIA surface expression requires interaction with an accessory chain, either the common  gamma -chain or CD3 zeta  (7, 8). Glycosylation patterns, electrophoretic mobility, and binding affinity appear to differ between NK cell and monocyte Fc gamma  RIIIA (9). Shed forms of both Fc gamma  RIIIA and Fc gamma  RIIIB can be generated by proteolytic cleavage and retain binding activity (10-13). Shedding from monocytes and macrophages can be triggered by cell activation or phagocytosis (13). Soluble Fc gamma  RIII circulates in normal plasma and is elevated in rheumatoid arthritis and in coronary artery diseases (11, 12).
 
全称：Low affinity immunoglobulin gamma Fc region receptor III-A (FCGR3A)
 
说明书：待上传