Anti-FGL2 Antibody, Rabbit Polyclonal

产品编号：PA00904HuA10
   
$ 询价

规格     50uL  100uL  200uL

产品名称：Anti-FGL2 Antibody, Rabbit Polyclonal

经验证的应用：/
 
交叉反应：/
 
特异性：human FGL2
 
免疫原：Recombinant human FGL2 protein, fragment Asn24~Pro439; UniprotKB: Q14314
 
制备方法：Produced in rabbits immunized with human FGL2, and purified by antigen affinity chromatography.

来源：Polyclonal Rabbit IgG
 
纯化：Immunogen affinity purified
 
缓冲液：Supplied in PBS, 50% glycerol and less than 0.02% sodium azide, PH7.4
 
偶联物：Unconjugated
 
状态：Liquid
 
运输方式：This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
储存条件：This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
 
别称：T49, PT49, Fibroleukin
 
背景信息：FGL2. FGL2 (fibrinogen-like protein 2), also called fibroleukin, is a 64-70kDa secreted glycoprotein of the Fibrinogen-like superfamily. It hasprothrombinase activity and also promotes T regulatory (Treg)activity (1-6). The human FGL2 gene encodes a 439 amino acid (aa)protein that contains a 23 aa signal sequence and a 416 aa maturesequence with a coiled-coil region and a fibronectin C-terminal homology domainor FRED (1, 2).  A 260-280 kDa FGL2 complex is thought to be atetramer formed by covalent disulfide linkage of dimers that are associated viacoiled-coil interactions (2, 3). Mature human FGL2 shares 79% aa identitywith mouse and rat FGL2. FGL2 appears to have two modes of action. One modeinvolves its prothrombinase activity, which requires calcium and acidicphospholipids (4). This mode is thought to be active during hepatitis viralinfections when FGL2, produced by macrophages in response to IFN-gamma, induceshepatic apoptosis and fibrin deposition (7). In addition, FGL2 produced byendothelial cells in response to TNF-alpha within cardiac xenografts orallografts promotes coagulation during acute vascular rejection (7-9). A secondmode of action involves soluble (not phospholipid-associated) FGL2 and isindependent of prothrombinase activity (2). Soluble FGL2 is required for Tregfunction, and directly suppresses DC, T, and B cell immune reactivity;consequently, some FGL2-deficent mice develop autoimmune glomerulonephritis (5, 6). In vitro, soluble FGL2 can skew T cell polarization towardTh2 and inhibit proliferation of stimulated T cells and maturation of DC(6). In pregnancy, fetal trophoblast cells secrete FGL2. The immune suppressivemode of FGL2 may prevent early fetal loss; however, the procoagulant mode isthought to mediate infection-triggered abortion (10). In the central nervoussystem (CNS), FGL2 was shown to be highly expressed in glioma stem cells andprimary glioblastoma cells and may serve as a critical immune oncology target(11).
 
全称：Fibroleukin (FGL2)
 
说明书：待上传