Anti-FGFR1 Antibody, Rabbit Polyclonal

产品编号：PA00377HuA10
   
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规格     50uL  100uL  200uL

产品名称：Anti-FGFR1 Antibody, Rabbit Polyclonal

经验证的应用：IF/ICC
 
交叉反应：/
 
特异性：human FGFR1
 
免疫原：Recombinant human FGFR1 protein, fragment Tyr236~Leu362; UniprotKB: P11362

制备方法：Produced in rabbits immunized with human FGFR1, and purified by antigen affinity chromatography.

来源：Polyclonal Rabbit IgG
 
纯化：Immunogen affinity purified
 
缓冲液：Supplied in PBS, 50% glycerol and less than 0.02% sodium azide, PH7.4
 
偶联物：Unconjugated
 
状态：Liquid
 
运输方式：This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
储存条件：This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
 
别称：CD331, FLT2, KAL2, CEK, FLG, BFGFR, N-SAM,Basic Fibroblast Growth Factor Receptor 1, Fms-Related Tyrosine Kinase-2, Pfeiffer Syndrome
 
背景信息：FGFR1. Fibroblast growth factor receptors (FGF Rs) are single-pass transmembrane proteins with extracellular fibroblast growth factor (FGF) binding domains and cytoplasmic tyrosine-protein kinase domains (1). FGF Rs play essential roles in the regulation of embryonic development, cell proliferation, differentiation and migration (2). Upon FGF and heparan sulfate binding, the FGF Rs form homodimers and the kinase domains are activated (3, 4). The activated kinases then phosphorylate downstream effector molecules such as PLC-g1, FRS2, Gab1, and SHB, leading to the activation of several signaling cascades (5). For example, activation of PLC-g1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate (6). Phosphorylation of FRS2 triggers recruitment of GRB2, Gab1, PI 3-Kinase p85, and SOS1, activation of Ras, ERK2, and ERK1, and activation of the MAP kinase and AKT1 signaling pathways (7). In this construct, the kinase domain of human FGF R1 is expressed as a constitutively active enzyme (8) and the activity was assayed using a phosphatase-coupled method (9).

全称：Fibroblast growth factor receptor 1 (FGFR1)
 
说明书：待上传