Anti-ICAM1 Antibody, Mouse Monoclonal

产品编号：PA00378MuA10
   
$ 询价

规格     50uL  100uL  200uL

产品名称：Anti-ICAM1 Antibody, Mouse Monoclonal

经验证的应用：/
 
交叉反应：/
 
特异性：mouse ICAM1
 
免疫原：Recombinant mouse ICAM1 protein, fragment Gln28~Asn485; UniprotKB: Q3U8M7

制备方法：Produced in rabbits immunized with mouse ICAM1, and purified by antigen affinity chromatography.

来源：Polyclonal Rabbit IgG
 
纯化：Immunogen affinity purified
 
缓冲液：Supplied in PBS, 50% glycerol and less than 0.02% sodium azide, PH7.4
 
偶联物：Unconjugated
 
状态：Liquid
 
运输方式：This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
储存条件：This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
 
别称：CD54, BB2, P3.58, Human Rhinovirus Receptor, Major group rhinovirus receptor
 
背景信息：ICAM-1/CD54. ICAM-1(Intercellular Adhesion Molecule-1), also known as CD54, is a transmembrane celladhesion glycoprotein and a member of the immunoglobulin supergene family. TheICAM sub-family consists of five members, ICAM-1 through ICAM-5, and they vary intheir tissue expression and number of Ig-like domains in the extracellulardomain (ECD). Full-length ICAM-1 contains five Ig-like domains in the ECD, asingle transmembrane domain and short intracellular domain. Alternativesplicing of ICAM-1 results in at least six membrane-bound forms and one solubleform (1). The ECD of mature, full-length human ICAM-1 shares 78% and 54% aminoacid sequence identity with rat and mouse ICAM-1, respectively. ICAM-1 plays animportant role in both innate and adaptive immune responses and is upregulated inendothelial and epithelial cells at sites of inflammation (2, 3). ICAM-1mediates vascular adhesion and paracellular migration of leukocytesexpressing activated LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) 2, 3). It alsobinds several non-integrin ligands including CD43/Sialophorin, Fibrinogen,Hyaluronan, rhinoviruses, and Plasmodium falciparum-infected erythrocytes (4-8).Soluble ICAM-1 promotes angiogenesis and serves as an indicator of vascularendothelial cell activation or damage (9). Elevated levels of soluble ICAM-1 areassociated with cardiovascular disease, type 2 diabetes, organ transplantdysfunction, oxidant stress, increased abdominal fat mass, hypertension, liverdisease, certain malignancies, and cerebral malaria (10-18). More recently,ICAM-1 was shown to be a novel regulator of group 2 innate lymphoid cells(ILC2s) which play a key role in allergic airway inflammation (19).

全称：Intercellular adhesion molecule 1 (ICAM1)
 
说明书：待上传