Anti-LGMN Antibody, Rabbit Polyclonal

产品编号：PA00396HuA10
   
$ 询价

规格     50uL  100uL  200uL

产品名称：Anti-LGMN Antibody, Rabbit Polyclonal

经验证的应用：IF/ICC
 
交叉反应：/
 
特异性：human LGMN
 
免疫原：Recombinant human LGMN protein, fragment Val18~Asn323; UniprotKB: Q99538

制备方法：Produced in rabbits immunized with human LGMN, and purified by antigen affinity chromatography.

来源：Polyclonal Rabbit IgG
 
纯化：Immunogen affinity purified
 
缓冲液：Supplied in PBS, 50% glycerol and less than 0.02% sodium azide, PH7.4
 
偶联物：Unconjugated
 
状态：Liquid
 
运输方式：This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
储存条件：This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
 
别称：AEP, LGMN1, PRSC1, Protease,Cysteine 1, Asparaginyl endopeptidase
 
背景信息：Legumain/Asparaginyl Endopeptidase. Legumain is a lysosomal cysteine protease whose activity is found in several tissues tested (1, 2). Legumain plays a pivotal role in the endosomal/lysosomal degradation system because the Legumain deficiency causes the accumulation of pro cathepsins B, H and L, another group of lysosomal cysteine proteases (3). Over-expression of Legumain in tumors is significant for invasion/metastasis (4). Also known as Asparaginyl Endopeptidase, it specifically cleaves peptide bonds with Asn at the P1 position. Nevertheless, it also cleaves peptide bonds with Asp at the P1 position. Auto-activation of pro Legumain involves both types of the cleavage, which result in the removal of the pro peptides in both C- and N-termini (5). In addition, Legumain activates pro MMP-2 and processes bacterial antigens for MHC class II presentation and pro thymosin  alpha  to thymosin  alpha 1 and thymosin  alpha 11, two acidic peptides with immunoregulatory properties (6‑8). Human Legumain is synthesized as a 433 amino acid precursor with a signal peptide (residues 1‑17). The pro enzyme (residues 18‑433) was expressed with an N-terminal His tag. This activity of Legumain can be inhibited by recombinant human Cystatins C and E/M and recombinant mouse Cystatin C (Catalog # 1196-PI, 1286-PI and 1238-PI, respectively).

全称：Legumain (LGMN)

说明书：待上传