Anti-TIMP1 Antibody, Rabbit Polyclonal

产品编号：PA00402HuA10
   
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规格     50uL  100uL  200uL

产品名称：Anti-TIMP1 Antibody, Rabbit Polyclonal

经验证的应用：IF/ICC
 
交叉反应：/
 
特异性：human TIMP1
 
免疫原：Recombinant human TIMP1 protein, fragment Cys24~Ala207; UniprotKB: P01033

制备方法：Produced in rabbits immunized with human TIMP1, and purified by antigen affinity chromatography.

来源：Polyclonal Rabbit IgG
 
纯化：Immunogen affinity purified
 
缓冲液：Supplied in PBS, 50% glycerol and less than 0.02% sodium azide, PH7.4
 
偶联物：Unconjugated
 
状态：Liquid
 
运输方式：This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
储存条件：This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
 
别称：EPO, CLGI, EPA, HCI, Erythroid Potentiating Activity, Collagenase Inhibitor, Metalloproteinase inhibitor 1, Fibroblast collagenase inhibitor
 
背景信息：TIMP-1. Tissue inhibitors of metalloproteinases or TIMPs are a family of homologous proteins that regulate the activity of matrix metalloproteinases (MMPs) (1, 2). There are four known members of the family, TIMP‑1, TIMP-2, TIMP-3 and TIMP-4 that have been found to exhibit multiple functions, including inhibition of active MMPs, proMMP activation, cell growth promotion, matrix binding, inhibition of angiogenesis and the induction of apoptosis. Structurally, TIMPs have two domains, an N‑terminal domain and a C‑terminal domain. Each domain consists of three disulfide-bonded loops. TIMP-1 is a glycoprotein produced by a wide range of cell types. Through its N‑terminal domain, TIMP-1 inhibits active MMPs by forming a non-covalent binary complex with the MMP active site. The C-terminal domain of TIMP-1 interacts with the C-terminal domain of proMMP-9, which may play a role in regulating proMMP-9 activation.

全称：Metalloproteinase inhibitor 1 (TIMP1)

说明书：待上传