Anti-BACE1 Antibody, Rabbit Polyclonal

产品编号：PA00424HuA10
   
$ 询价

规格     50uL  100uL  200uL

产品名称：Anti-BACE1 Antibody, Rabbit Polyclonal

经验证的应用：/
 
交叉反应：/
 
特异性：human BACE1
 
免疫原：Recombinant human BACE1 protein, fragment Phe170~Thr428; UniprotKB: P56817

制备方法：Produced in rabbits immunized with human BACE1, and purified by antigen affinity chromatography.

来源：Polyclonal Rabbit IgG
 
纯化：Immunogen affinity purified
 
缓冲液：Supplied in PBS, 50% glycerol and less than 0.02% sodium azide, PH7.4
 
偶联物：Unconjugated
 
状态：Liquid
 
运输方式：This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
储存条件：This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
 
别称：ASP2, Beta Secretase, Memapsin 2, Aspartyl protease 2, Beta-site amyloid precursor protein cleaving enzyme 1, Membrane-associated aspartic protease 2
 
背景信息：BACE-1. BACE-1 is an aspartic protease and an integral membrane protein (1, 2). It is the major  beta  secretase, and together with the  gamma  secretase, is responsible for generating the amyloid  beta  peptide (A beta ) from the amyloid precursor protein (APP) (3, 4). Because A beta  is a major component of amyloid plaques, BACE-1 has been implicated in the onset and/or progression of Alzheimer's disease. High levels of BACE-1 activity are sufficient to elicit neurodegeneration and neurological decline in vivo, indicating that inhibiting BACE-1 may block not only A beta -dependent but also A beta -independent pathogenic mechanisms (5). In addition to APP, BACE-1 also cleaves APP-like proteins 1 and 2, the cell adhesion protein P-selectin glycoprotein ligand-1 and  beta -galactoside  alpha 2,6-sialyltransferase, implying that BACE-1 may have additional functions involving the ectodomain shedding of membrane proteins (6-8). The purified recombinant mouse BACE-1 corresponds to the ectodomain with the activity as described in Activity Assay Protocol.

全称：Beta-secretase 1 (BACE1)

说明书：待上传